186371-96-0
中文名称
FUDAEUIGIJZUAY-UMIRZPQISA-N
英文名称
FUDAEUIGIJZUAY-UMIRZPQISA-N
CAS
186371-96-0
分子式
C32H46O5
分子量
510.7
MOL 文件
186371-96-0.mol
186371-96-0 结构式
物理化学性质
沸点652.9±55.0 °C(Predicted)
密度1.15±0.1 g/cm3(Predicted)
储存条件4°C, protect from light, stored under nitrogen
酸度系数(pKa)14.29±0.20(Predicted)
形态Solid
颜色White to off-white
FUDAEUIGIJZUAY-UMIRZPQISA-N价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-12407 | FUDAEUIGIJZUAY-UMIRZPQISA-N ZK168281 | 186371-96-0 | 1mg | 8500元 |
常见问题列表
生物活性
ZK168281 是一种 1α,25(OH)2D3 类似物，也是一种纯 VDR 拮抗剂，Kd 值为 0.1 nM。ZK168281 是其受体 CoA 相互作用的有效抑制剂。靶点
Kd: 0.1 nM (VDR)
体外研究
ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus.