1568-80-5
1568-80-5 结构式
基本信息
螺二茚满
3,3,3',3'-四甲基螺环二酚
3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇
3,3,3',3'-四甲基-2,2',3,3'-四氢-1,1'-螺二[茚满]-6,6'-二醇
SPIROBIINDANE
-tetrahydro-1,1'
-tetramethyl-2,2'
-spirobi[indene]-6,6'
HIV-1 integrase inhibitor 8
3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol
tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan
6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane
物理化学性质
安全数据
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 50mg | 500元 |
| 2024/01/25 | HY-107485 | 3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 HIV-1 integrase inhibitor 8 | 1568-80-5 | 100mg | 800元 |
常见问题列表
HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn 2+ as the cationic cofactor by gel assay with IC 50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC 50 value of 200 µM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC 50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD 50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.