161180-11-6
中文名称
UMBELLIFERYL ARACHIDONATE
英文名称
UMBELLIFERYL ARACHIDONATE
CAS
161180-11-6
分子式
C29H36O4
分子量
448.59
MOL 文件
161180-11-6.mol
更新日期
2024/07/05 14:14:18
161180-11-6 结构式
基本信息
英文别名
7-HC-ARACHIDONATEUMBELLIFERYL ARACHIDONATE
SFTGFGOBCQCZDY-DOFZRALJSA-N
7-HYDROXYCOUMARINYL ARACHIDONATE
ARACHIDONATE 2-OXO-2H-1-BENZOPYRAN-7-YL ESTER
5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID 7-HYDROXYCOUMARINYL
5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID, 2-OXO-2H-1-BENZOPYRAN-7-YL ESTER
5,8,11,14-Eicosatetraenoic acid, 2-oxo-2H-1-benzopyran-7-yl ester, (5Z,8Z,11Z,14Z)-
7-Hydroxycoumarinyl Arachidonate, 5Z,8Z,11Z,14Z-Eicosatetraenoic acid 2-oxo-2H-1-benzopyran-7-yl ester
物理化学性质
沸点584.7±50.0 °C(Predicted)
密度1.052±0.06 g/cm3(Predicted)
闪点14 °C
储存条件−20°C
溶解度≤25mg/ml in DMSO;50mg/ml in dimethyl formamide
形态ethanol solution
颜色Colorless to light yellow
常见问题列表
生物活性
7-Hydroxycoumarinyl arachidonate (7-HCA) 是胞质磷脂酶 A2 (PLA2) 的荧光底物，也是单酰基甘油脂肪酶 (MAGL) 的荧光底物。MAGL 蛋白催化 7-Hydroxycoumarinyl arachidonate 的水解，生成花生四烯酸 (AA；HY-109590) 和高荧光的 7-羟基香豆素 (7-HC；HY-N0573)，7-HC 的释放可以用荧光计进行测量。体外研究
MAGL catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonate (7-HCA) into arachidonic acid (AA) and 7-HC. Release of 7-HC, which is fluorescent, is monitored over time with excitation (Ex) at 355 nm and emission (Em) at 460 nm.