88070-98-8
中文名称
BROMOENOL LACTONE
英文名称
BROMOENOL LACTONE
CAS
88070-98-8
分子式
C16H13BrO2
分子量
317.18
MOL 文件
88070-98-8.mol
88070-98-8 结构式
基本信息
中文别名
化合物 T14829 英文别名
BELHELSS
HALOENOL LACTONE
BROMOENOL LACTONE
(6E)-Bromoenol lactone
Bromoenol lactone (BEL)
Bromoenol Lactone Solution
HALOENOL LACTONE SUICIDE SUBSTRATE
(6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
E-6-(BROMOETHYLENE)TETRAHYDRO-3-(1-NAPHTHYL)-2H-PYRAN-2-ONE
物理化学性质
熔点103-106℃
沸点467.0±45.0 °C(Predicted)
密度1.538±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble
形态白色固体。
颜色White to yellow
常见问题列表
生物活性
Bromoenol lactone ((6E)-Bromoenol lactone) 是一种不可逆的选择性的和有效的钙依赖性磷脂酶 A2 (iPLA2β) 抑制剂，其 IC50 值约为 7 μM，可抑制抗原刺激的肥大细胞胞吐作用，而不会阻止 Ca2+ 的大量涌入。靶点
|
PLA2 7 μM (IC 50 ) |
体外研究
In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca 2+ entry is critical for exocytosis. Bromoenol lactone inhibits exocytosis when stimulated using a Ca 2+ ionophore A23187, which passively transports Ca 2+ down a concentration gradient and also in permeabilised mast cells where Ca 2+ entry is no longer relevant. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca 2+ signalling, both the release from internal stores and sustained elevation due to Ca 2+ influx.