16561-29-8
![16561-29-8 结构式](/CAS/GIF/16561-29-8.gif)
基本信息
豆蔻酰佛波醇乙酯
乙酸佛波酯 PMA
乙酸佛波酯
12-TETRADECANOYL PHORBOL 13-ACETATE
(1AR,1BS,4AR,7AS,7BS,8R,9R,9AS)-9A-(ACETYLOXY)-1A,1B,4,4A,5,7A,7B,8,9,9A-DECAHYDRO-4A,7B-DIHYDROXY-3-(HYDROXYMETHYL)-1,1,6,8-TETRAMETHYL-5-OXO-1H-CYCLOPROPA[3,4]BENZ[1,2-E]AZULEN-9-YL TETRADECANOATE
4ALPHA,9ALPHA,12BETA,13ALPHA,20-PENTAHYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4BETA,9ALPHA,12BETA,13ALPHA,20-PENTA-HYDROXYTIGLIA-1,6-DIEN-3-ONE 12BETA-MYRISTATE 13-ACETATE
4BETA-PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL 12-MYRISTATE 13-ACETATE
PHORBOL (12-MYRISTOYL-13-ACETYL)
PMA
TPA
,9aalpha))-
1,6,8-beta-tetramethyl-l)-9a-acetate9-myristate
12-o-tetradecanoylphorbolacetate
12-o-tetradekanoylphorbol-13-acetat
12-tetradecanoylphorbol13-monoacetate
13-o-acetylphorbol12-myristate
4)benz(1,2-e)azulen-5-one9a-acetate,(+)-ethyl-5h-cyclopropa(
5h-cyclopropa(3,4)benz(1,2-e)azulen-5-one,1,1a-beta,1b-alpha,4,4a,7a-beta,7b,
8,9,9a-decahydro-4a-alpha,7b-beta,9-alpha,9a-beta-tetrahydroxy-3-(hydroxymethy
abeta,7balpha,9beta,9aalpha-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8alpha-tetram
物理化学性质
安全数据
16561-29-8(安全特性,毒性,储运)
常见问题列表
PKC 11.7 nM (EC 50 ) |
In order to examine the role of PKC in p38MAPK phosphorylation, the cells are stimulated with the PKC activator, PMA (100 nM), which mimics the binding of DAG, the natural activator of PKC, to the C1 region of the PKCs. p38MAPK phosphorylation by PMA is observed in the two cell types similar to that observed by GnRH in αT3-1 cells, that is, a slow sustained activation (3.2-fold and 3.6-fold, respectively at 30 min). The paradoxical findings that PKCs activated by GnRH and PMA play a differential role in p38MAPK phosphorylation may be explained by differential localization of the PKCs. Basal, GnRH- and PMA- stimulation of p38MAPK phosphorylation in αT3-1 cells is mediated by Ca
2+
influx via voltage-gated Ca
2+
channels and Ca
2+
mobilization, while in the differentiated LβT2 gonadotrope cells it is mediated only by Ca
2+
mobilization.
THP-1 cells are differentiated into macrophage-like cells (THP-1 macrophages) by incubation in the presence of PMA (200 ng/mL; 1-5 days), which leads to a macrophage-like phenotype characterized by changes in morphology and increased cell surface expression of CD11 and CD14.
In the monocytic cell line THP-1, PMA results in a more differentiated phenotype than VD3, according to adherence, loss of proliferation, phagocytosis of latex beads, and expression of CD11b and CD14.
PMA is a PKC agonist, which reverses the damage induced by 5-hydroxydecanoic acid (5-HD). Thus, activation of the mitoKATP protected mitochondrial function in SOD and MDA via the PKC pathway.
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | 35615 | 佛波醇12-十四酸酯13-乙酸酯 Phorbol 12-myristate 13-acetate, 97%, Thermo Scientific Chemicals | 16561-29-8 | 1mg | 1731元 |
2024/08/19 | 35615 | 佛波醇12-十四酸酯13-乙酸酯 Phorbol 12-myristate 13-acetate, 97%, Thermo Scientific Chemicals | 16561-29-8 | 5mg | 6166元 |
2024/08/19 | HY-18739 | 佛波醇12-十四酸酯13-乙酸酯 Phorbol 12-myristate 13-acetate | 16561-29-8 | 1mg | 550元 |