168266-90-8

中文名称 VOFOPITANT

英文名称 GR 205171

CAS 168266-90-8

分子式 C21H23F3N6O

分子量 432.44

MOL 文件 168266-90-8.mol

168266-90-8 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T13329

英文别名

GR 205171
Vofopitant
Vofopitant (GR 205171)
3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluormethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl, (2S,3S)
3-Piperidinamine, N-[[2-methoxy-5-[5-(trifluormethyl)-1H-tetrazol-1-yl]phenyl]methyl]-2-phenyl, (2S-cis-)

物理化学性质

沸点542.5±60.0 °C(Predicted)

密度1.39±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)9.13±0.10(Predicted)

形态Solid

颜色Light yellow to yellow

CAS 数据库168266-90-8

常见问题列表

生物活性

Vofopitant 是一种有效的 NK1 receptor 拮抗剂，对人，大鼠和雪貂的 NK1 receptor 的 pKi 值分别为 10.6，9.5 和 9.8。

靶点

pKi: 10.6 (Human NK ₁ receptor), 9.5 (Rat NK ₁ receptor), 9.8 (Ferret NK ₁ receptor)

体外研究

Vofopitant is potent tachykinin NK ₁ receptor antagonist, with pK _i s of 10.6, 9.5, and 9.8 for human, rat and ferret NK ₁ receptor, respectively. Vofopitant less potently inhibits rat 5-HT1A, bovine 5-HT1D, rat 5-HT2A, rat Histamine H1, guinea-pig Histamine H2 and rat Ca ²⁺ channel, with pK _i s of 6.3, 6.6, 6.5, 6.5, 6.6, and 5.6, respectively. Vofopitant shows negligible affinity at NK ₂ and NK ₃ , with pIC ₅₀ of <5.0. GR205171 (300 µM) potentiates the effects of paroxetine on cortical [5-HT]ext, and inhibits paroxetine-induced increase in [5-HT]ext in the dorsal raphe nucleus.

体内研究

Vofopitant (GR205171, 30 mg/kg, s.c.) increases the number of choices of the 25-s delayed reward in a T-maze. Vofopitant (GR205171, 30 mg/kg, i.p.) increases the extracellular 5-HT levels in the frontal cortex of paroxetine-treated wild-type mice, rather than in wild-type mice and paroxetine-treated NK1 receptor knockout mice.