168425-64-7

中文名称 COMPOUND 401

英文名称 COMPOUND 401

CAS 168425-64-7

分子式 C16H15N3O2

分子量 281.314

MOL 文件 168425-64-7.mol

更新日期 2023/03/20 15:41:19

168425-64-7 结构式

基本信息物理化学性质安全数据 COMPOUND 401价格(试剂级) 常见问题列表

基本信息

中文别名

化合物COMPOUND 401
2-吗啉-4H-嘧啶并[2,1-A]异喹啉-4-酮
2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮
2-(吗啉-4-基)嘧啶并[2,1-A]异喹啉-4-酮
2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮
2-MORPHOLINO-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE 2-吗啉基-4H-嘧啶并[2,1-A]异喹啉-4-酮

英文别名

CS-315
Morpholino a
Compound 401, >=98%
COMPOUND401
COMPOUND-401
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one
2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one>
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
4H-PyriMido[2,1-a]isoquinolin-4-one, 2-(4-Morpholinyl)-
2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

物理化学性质

熔点184-186℃ (ethanol )

沸点456.9±55.0 °C(Predicted)

密度1.36±0.1 g/cm3 (20 ºC 760 Torr)

储存条件Store at RT

溶解度DMSO : 6 mg/mL (21.33 mM; Need ultrasonic and warming)

酸度系数(pKa)1.01±0.20(Predicted)

形态粉末晶体

颜色白色至浅黄色

CAS 数据库168425-64-7

安全数据

海关编码2934.99.4400

COMPOUND 401价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	M2537	2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	168425-64-7	10mg	250元
2024/04/30	M2537	2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮 2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one	168425-64-7	50mg	955元
2024/04/30	S6506	COMPOUND 401 Compound 401	168425-64-7	5mg	958.97元

常见问题列表

生物活性

Compound 401是DNA-PK和mTOR抑制剂（IC50分别为0.28 μM和5.3 μM）。它对p110α/p85α PI3K没有明显抑制作用，在COS7细胞中抑制S6激酶在Thr389位的磷酸化和Akt在Ser473位的磷酸化。

靶点

Target	Value
DNA-PK (Cell-free assay)	0.28 μM
mTOR (Cell-free assay)	5.3 μM

体外研究

Compound 401 is a potent inhibitor of DNA-PK (IC ₅₀ =0.28 μM). Compound 401 is reported to be a poor inhibitor of PI3K, ATM, and ATR in vitro, but it is active against mTOR. Compound 401 shows activity against mTOR (IC ₅₀ =5.3 μM) but not p110α/p85α PI3K (IC ₅₀ >100 μM). Treatment of cells with Compound 401 blocks the phosphorylation of sites modified by mTOR-Raptor and mTOR-Rictor complexes (ribosomal protein S6 kinase 1 Thr ³⁸⁹ and Akt Ser ⁴⁷³ , respectively). By contrast, there is no direct inhibition of Akt Thr ³⁰⁸ phosphorylation, which is dependent on PI3K. Similar effects are also observed in cells that lack DNA-PK. Compound 401 inhibits immunoprecipitated epitope-tagged mTOR or endogenous mTOR in Raptor immunoprecipitates. In both cases, inhibition of 67% or 78% is obtained at 5 μM or 10 μM Compound 401, respectively. By contrast, dose response curves show that the p110α/p85α or p110β/p85α PI3K complexes are poorly inhibited by Compound 401 at these concentrations. The proliferation of TSC1 ^-/- fibroblasts is inhibited in the presence of Compound 401, but TSC1 ^+/+ cells are resistant.