17598-65-1
中文名称
去乙酰西地兰
英文名称
Deslanoside
CAS
17598-65-1
EINECS 编号
241-568-1
分子式
C47H74O19
MDL 编号
MFCD00135818
分子量
943.08
MOL 文件
17598-65-1.mol
更新日期
2024/02/02 15:51:05
![17598-65-1 结构式](/CAS/GIF/17598-65-1.gif)
基本信息
中文别名
毛花强心苷丙去乙酰毛花苷丙
西地兰
去乙酰毛花苷
毛地黄苷C
毛花洋地黄苷C
乙酰地谷新葡萄糖苷
去乙酰西地兰
英文别名
DEACETYLLANATOSIDE CDESLANOSIDE
DESLANOSIDUM
cedilanidd
deacetyl-lanatoside
desacetyllanatosidec
descetyldigilanidec
deslanatoside
sediranido
Deslanoside (JP14/USP)
Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
Deacetylanatoside C
De-O-acetyllanatoside C
Desace
Desaci
Deslanatoside C
Deslanoside C
Lanatoside C, deacetyl- (6CI, 7CI, 8CI)
Purpurea glycoside C
Desacetyl-Lanatosid C
所属类别
原料药:抗充血性心力衰竭药物理化学性质
熔点220-235°C
比旋光度D20 +12° (c = 1.084 in 75% alc)
沸点732.1°C (rough estimate)
密度1.1255 (rough estimate)
折射率1.6500 (estimate)
储存条件2-8°C
溶解度DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
酸度系数(pKa)12.89±0.70(Predicted)
形态neat
颜色White to off-white
安全数据
警示词危险
危险性描述H301+H331-H373
危险类别码R23/25-R33
安全说明S1-S22-S45
危险品运输编号2811
海关编码2938900000
毒性cat,LD50,intravenous,230ug/kg (0.23mg/kg),"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 190, 1963.
常见问题列表
简介
去乙酰毛花苷呈白色结晶性粉末状;无臭,味苦;有引湿性。本品在甲醇中微溶,在乙醇中极微溶解,在水或氯仿中几乎不溶。
适应症
用于急性和慢性心力衰竭、心房颤动和阵发性室上性心动过速。由于本品在溶液中不如去乙酰毛花苷稳定,故注射多采用后者。本品仅有时用于口服给药,但因从胃肠道吸收不如洋地黄毒苷,且吸收不规则,现口服亦较少应用。生物活性
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。Deslanoside 抑制 Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。体外研究
Deslanoside (Desacetyllanatoside C) is a metabolite of Lanatoside C. Deslanoside increases forearm blood flow and cardiac index and decreased heart rate concomitant with a marked decrease in skeletal muscle sympathetic nerve activity measured as an indicator of centrally mediated sympathetic nervous system activity.