193001-14-8
中文名称
ZM323881
英文名称
5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL
CAS
193001-14-8
分子式
C22H18FN3O2
分子量
375.4
MOL 文件
193001-14-8.mol
更新日期
2024/07/23 19:08:37
![193001-14-8 结构式](/StructureFile/ChemBookStructure21/GIF/CB6811963.gif)
基本信息
中文别名
4-氟-2-甲基-5-[[7-(苯基甲氧基)-4-喹唑啉基]氨基]苯酚 英文别名
CS-744ZM323881
KDR/FLK-1 INHIBITOR V
VEGF RECEPTOR 2 KINASE INHIBITOR V
5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL
4-Fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]phenol
Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-
所属类别
生物:小分子化合物物理化学性质
沸点543.6±50.0 °C(Predicted)
密度1.342±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)9.99±0.23(Predicted)
形态白色至类白色固体
常见问题列表
生物活性
ZM323881是有效,选择性的 VEGFR2 抑制剂, IC50 值小于2 nM。靶点
VEGFR2 2 nM (IC 50 ) |
体外研究
ZM323881 is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity anddemonstrates excellent selectivity versus other receptor tyrosine kinases, including PDGFRβ, FGFR1, EGFR and erbB2 (IC 50 >50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation(IC 50 =8 nM) and VEGFR2 tyrosine phosphorylation. ZM323881 inhibits activation of VEGFR-2, but not of VEGFR-1, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), or hepatocyte growth factor (HGF) receptor. In HAECs, ZM323881 completely inhibits VEGF-induced ERK phosphorylation at 1 μM.