210344-98-2
![210344-98-2 结构式](/StructureFile/ChemBookStructure6/GIF/CB9280050.gif)
基本信息
(5S,8S,11S,14S)-5-((S)-仲丁基)-14-(2-氟乙酰基)-11-((R)-1-羟乙基)-8-(3-甲氧基-3-氧代丙基)-3,6,9,12-四氧代-1-苯基-2-氧杂-4,7,10,13-四氮杂十六烷-16-酸甲酯
Z-IETD-FMK?, >98%
Z-IE(OME)TD(OME)-FMK
CASPASE-8 INHIBITOR II
GRANZYME B INHIBITOR III
Z-ILE-GLU(OME)-THR-ASP(OME)-FMK
Z-IE(OME)TD(OME)-FLUOROMETHYLKETONE
CASPASE-8 INHIBITOR
Z-IE(OME)TD(OME)-FMK
Z-ILE-GLU(OME)-THR-ASP(OME)-FLUOROMETHYLKETONE
Z-ILE-GLU(OME)-THR-DL-ASP(OME)-FLUOROMETHYLKETONE
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | S7314 | CASPASE-8抑制剂 Z-IETD-FMK | 210344-98-2 | 1mg | 1624.01元 |
2024/08/19 | S7314 | CASPASE-8抑制剂 Z-IETD-FMK | 210344-98-2 | 5mg | 4832.1元 |
2024/08/19 | S7314 | Z-IETD-FMK | 210344-98-2 | 10mM (1mL in DMSO) | 5561.01元 |
常见问题列表
Target | Value |
Caspase-8 |
Z-IETD-FMK causes full inhibition only of the proapoptotic effect of TNFα with an IC 50 of 0.46 μM. Z-IETD-FMK and Z-VAD-FMK at non-toxic doses are found to be immunosuppressive and inhibit human T cell proliferation induced by mitogens and IL-2. They are shown to block NF-κB in activated primary T cells, but have little inhibitory effect on the secretion of IL-2 and IFN-γ during T cell activation. Z-IETD-FMK inhibits the cleavage of caspase-8 and only partially inhibits the cleavage of caspase-3 and PARP. Z-IETD-FMK can prevent the execution of apoptosis in retinal cells exposed to different apoptotic stimuli.
Pharmacological inhibition of caspase-8 by z-IETD-FMK robustly reduces tumour outgrowth and this is closely associated with a reduction in the release of pro-inflammatory cytokines, IL-6, TNF-α, IL-18, IL-1α, IL-33, but not IL-1β. Furthermore, inhibition of caspase-8 reduces the recruitment of innate suppressive cells, such as myeloid-derived suppressor cells, but not of regulatory T cells to lungs of tumour-bearing mice.