2123489-30-3

中文名称 ALLOSTERIC WNK KINASE INHIBITOR

英文名称 Allosteric WNK Kinase Inhibitor ,

CAS 2123489-30-3

分子式 C21H21Cl2N5OS

分子量 462.4

MOL 文件 2123489-30-3.mol

更新日期 2024/08/02 14:00:36

2123489-30-3 结构式

基本信息物理化学性质图谱信息 ALLOSTERIC WNK KINASE INHIBITOR价格(试剂级) 常见问题列表

基本信息

中文别名

化合物WNK-IN-11
5-氯-2-[2-(甲氨基)-4-噻唑基]-4-吡啶基][4-[(4-氯苯基)甲基]-1-哌嗪基]-甲酮

英文别名

WNK-IN-11
ALLOSTERIC WNK KINASE INHIBITOR
Allosteric WNK Kinase Inhibitor ,
WNK-IN-11
WNK IN 11
WNKIN11
WNK INHIBITOR 11
WNK INHIBITOR-11
2123489-30-3
(5-Chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone
Methanone, [5-chloro-2-[2-(methylamino)-4-thiazolyl]-4-pyridinyl][4-[(4-chlorophenyl)methyl]-1-piperazinyl]-

物理化学性质

沸点641.1±65.0 °C(Predicted)

密度1.407±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; DMSO: 25 mg/ml; Ethanol: 3 mg/ml

酸度系数(pKa)5.52±0.10(Predicted)

形态结晶固体

颜色White to off-white

图谱信息

ALLOSTERIC WNK KINASE INHIBITOR(2123489-30-3)核磁图(¹HNMR)

ALLOSTERIC WNK KINASE INHIBITOR价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-112094	ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11	2123489-30-3	10mM * 1mLin DMSO	2340元
2024/04/30	S0015	ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11	2123489-30-3	5mg	3550.96元
2024/04/30	HY-112094	ALLOSTERIC WNK KINASE INHIBITOR WNK-IN-11	2123489-30-3	10mg	3800元

常见问题列表

生物活性

WNK-IN-11 是一种有效的、具有选择性的 With-No-Lysine (WNK) 的口服活性变构抑制剂，对WNK1酶的IC50为4 nM。

靶点

Target	Value
WNK1 (Cell-free assay)	4 nM

体外研究

WNK-IN-11 (compound 11) shows IC ₅₀ <2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC ₅₀ value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket.