2365478-58-4
中文名称
(2S,4R)-N-(2-(2-(2-(2-((6-氯己基)氧基)乙氧基)乙氧基)乙氧基)-4-(4-甲基噻唑-5-基)苄基)-1-((S)-2-(1-氰基环丙烷甲酰胺)-3,3-二甲基丁酰基)-4-羟基吡咯烷-2-甲酰胺
英文名称
INDEX NAME NOT YET ASSIGNED
CAS
2365478-58-4
分子式
C39H56ClN5O8S
分子量
790.41
MOL 文件
2365478-58-4.mol
更新日期
2024/07/24 18:26:20
2365478-58-4 结构式
基本信息
中文别名
(2S,4R)-N-(2-(2-(2-(2-((6-氯己基)氧基)乙氧基)乙氧基)乙氧基)-4-(4-甲基噻唑-5-基)苄基)-1-((S)-2-(1-氰基环丙烷甲酰胺)-3,3-二甲基丁酰基)-4-羟基吡咯烷-2-甲酰胺 英文别名
HaloPROTAC-E物理化学性质
沸点983.9±65.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
酸度系数(pKa)12.28±0.20(Predicted)
形态Oil
颜色Colorless to light yellow
应用领域
用途一
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded.