303126-97-8
中文名称
303126-97-8
英文名称
SR 0987
CAS
303126-97-8
分子式
C16H10ClF6NO2
分子量
397.7
MOL 文件
303126-97-8.mol
更新日期
2024/06/25 17:15:56
![303126-97-8 结构式](/CAS/20200611/GIF/303126-97-8.gif)
基本信息
中文别名
化合物SR0987 英文别名
SR 0987SR0987 >=98% (HPLC)
SR 0987
SR-0987
SR0987
303126-97-8
2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
Benzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
物理化学性质
沸点378.8±42.0 °C(Predicted)
密度1.525±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Store in freezer, under -20°C
溶解度可溶于DMSO(至少25mg/ml)和乙醇(至少25mg/ml)
酸度系数(pKa)9.22±0.15(Predicted)
形态固体
颜色白色
稳定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
303126-97-8价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-101454 | 303126-97-8 SR0987 | 303126-97-8 | 5mg | 800元 |
2024/04/30 | HY-101454 | 303126-97-8 SR0987 | 303126-97-8 | 10mM * 1mLin DMSO | 880元 |
2024/04/30 | S0094 | 303126-97-8 SR 0987 | 303126-97-8 | 5mg | 890.46元 |
常见问题列表
生物活性
SR 0987 是一种SR 1078的类似物,是 T cell-specific RORγ (RORγt) 的激动剂,EC50值为800 nM。SR 0987 可抑制 PD-1,生成 IL17,并具有治疗癌症的潜力。靶点
Target | Value |
PD-1
() | |
IL17
() | |
RORγt
(Cell-free assay) | 800 nM(EC50) |
体外研究
SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC 50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production.