324054-99-1
英文名称
N-[2-(aminocarbonyl)phenyl][1,1'-biphenyl]-4-carboxamide
CAS
324054-99-1
分子式
C20H16N2O2
分子量
316.35
MOL 文件
324054-99-1.mol
324054-99-1 结构式
基本信息
英文别名
N-(2-carbamoylphenyl)biphenyl-4-carboxamideN-[2-(aminocarbonyl)phenyl][1,1'-biphenyl]-4-carboxamide
[1,1'-Biphenyl]-4-carboxamide, N-[2-(aminocarbonyl)phenyl]-
应用领域
用途一
APBC is a novel PD-L1 inhibitor, effectively interrupting the PD-1/PD-L1 interaction by directly binding to PD-L1, presenting the KD and IC50 values at low-micromolar level, displaying superior antitumor efficacy in hPD-L1 knock-in B16F10-bearing mouse model without the induction of observable liver toxicity.