339068-25-6
中文名称
化合物 T11556
英文名称
HET0016
CAS
339068-25-6
分子式
C12H18N2O
分子量
206.28
MOL 文件
339068-25-6.mol
更新日期
2023/03/20 15:41:27
339068-25-6 结构式
基本信息
中文别名
化合物 T11556N'-(4-丁基-2-甲基苯基)-N-羟基甲脒
N-羟基-N'-(4-正丁基-2-甲基苯基)甲IDINE
N-(4-丁基-2-甲基苯基)-N'-羟基甲基亚氨基酰胺
英文别名
HET0016N-Hydroxy-N(4-butyl-2-methylphenyl)formamidine
N-HYDROXY-N'-(4-N-BUTYL-2-METHYLPHENYL)FORMANIDINE
N’-(4-Butyl-2-methylphenyl)-N-hydroxyformimidamide
N-(4-butyl-2-methylphenyl)-N'-hydroxyiminoformamide
N-(4-BUTYL-2-METHYLPHENYL)-N'-HYDROXY-METHANIMIDAMIDE
Methanimidamide, N'-(4-butyl-2-methylphenyl)-N-hydroxy-
物理化学性质
熔点138-140°C
储存条件Hygroscopic, -20°C Freezer, Under inert atmosphere
溶解度可溶于氯仿（少许）、乙醇（少许）
形态淡粉色固体。
颜色白色至淡黄色
CAS 数据库339068-25-6
应用领域
用途1
生物试剂用途2
HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other
CYP鈥檚: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models.
Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).