496864-16-5
中文名称
7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
英文名称
RP107
CAS
496864-16-5
分子式
C16H17N3O
分子量
267.33
MOL 文件
496864-16-5.mol
496864-16-5 结构式
基本信息
中文别名
4-(7-丁基-5H-吡咯并[2,3-B]吡嗪-6-基)苯酚7-丁基-6-(4-羟基苯基)-5H-吡咯并[2,3-B]吡嗪
英文别名
RP107ALOISINE A
ALOISINE A RP107
4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL
7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
物理化学性质
熔点281-283°C
密度1.227
储存条件-20?C Freezer
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)9.67±0.15(Predicted)
形态黄色固体
颜色浅橙黄色
应用领域
用途1
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk
1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively). Also inhibits the activity of clycogen synthase kinase-3 (GSK-3,:(IC50 =500 nM and 1.5 uM for GSK-3a, GSK-3脽, respectively), and
c-Jun N-terminal kinase (JNK: IC50 approx. 3-10uM).