50-49-7
中文名称
米帕明
英文名称
IMIPRAMINE
CAS
50-49-7
分子式
C19H24N2
分子量
280.41
MOL 文件
50-49-7.mol
更新日期
2023/03/20 15:41:19
50-49-7 结构式
基本信息
中文别名
米帕明丙米嗪
氯米帕明杂质10
化合物 T20025
丙咪嗪(氯丙咪嗪EP杂质B)
丙咪嗪系统适应性 EP标准品
英文别名
IMDPID
Irmin
Iramil
Imizin
Imiprin
Imizine
Surplix
Timolet
Censtim
所属类别
原料药:抗抑郁、躁狂药物理化学性质
熔点174°C
沸点bp0.1 160°
密度0.9935 (rough estimate)
折射率1.5640 (estimate)
酸度系数(pKa)pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
形态Liquid
颜色Colorless to light yellow
水溶解性18.23mg/L(24 ºC)
Concentration1 mCi/ml
SolventEthanol under nitrogen
Specific Activity60-90 Ci/mmol
BCS Class1
EPA化学物质信息Imipramine (50-49-7)
安全数据
警示词危险
危险性描述H302-H336-H370-H400
毒性A tertiary amine tricyclic antidepressant that is thought
to exert its therapeutic effect by inhibiting the reuptake of serotonin
and norepinephrine centrally. A major metabolite is N-desmethylimipramine
(desipramine), also used as an antidepressant
drug. Desipramine differs from imipramine in being a better
blocker of norepinephrine, rather than serotonin, uptake. Side
effects, including sedation and drowsiness, dry mouth, urinary
retention, constipation, and orthostatic hypotension, are probably
due to the anticholinergic, anti-α-adrenergic, and antihistaminergic
receptor-blocking properties. Imipramine should not be used
in conjunction with a monoamine oxidase inhibitor or other
treatment that increases catecholamine concentrations (e.g.,
drugs containing sympathomimetic amines). Imipramine should
be avoided in patients with cardiovascular disease or seizure disorder,
or in those who may abuse alcohol, as imipramine lowers
seizure threshold, can produce cardiovascular toxicity and may
potentiate the effects of alcohol. Imipramine intoxication can
include CNS abnormalities (e.g., drowsiness, stupor, coma, and
extrapyramidal symptoms), cardiac arrhythmia, and respiratory
depression. Children appear to be particularly vulnerable to the
cardiotoxic and seizure-inducing effects of high doses of imipramine.
The oral LD50 in female rats is 305 mg/kg.