51165-05-0
中文名称
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME: RPKPQQFFGLM-OME
英文名称
SUBSTANCE P (7-11)
CAS
51165-05-0
分子式
C31H44N6O5S
分子量
612.78
MOL 文件
51165-05-0.mol
51165-05-0 结构式
基本信息
中文别名
N-(1-AMINO-4-METHYLSULFANYL-1-OXOBUTAN-2-YL)-2-[[2-[[2-[(2-AMINO-3-PHENYLPROPANOYL)AMINO]-3-PHENYLPROPANOYL]AMINO]ACETYL]AMINO]-4-METHYLPENTANAMIDE 英文别名
FFGLM-NH2PENTA-SUBSTANCE P
SUBSTANCE P (7-11)
Substance P 7-11(TFA)
PHE-PHE-GLY-LEU-MET-NH2
SUBSTANCE P FRAGMENT 7-11
H-PHE-PHE-GLY-LEU-MET-NH2
L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
SUBSTANCE P FRAGMENT 7-11 ACETATE)
L-Phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
物理化学性质
沸点1003.3±65.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble in DMSO
酸度系数(pKa)13.26±0.46(Predicted)
形态固体
颜色White to off-white
常见问题列表
生物活性
Substance P (7-11) 是神经肽物质P的C-末端片段，其可引起细胞内钙浓度的增加。体外研究
Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM.