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51165-05-0

中文名称 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME: RPKPQQFFGLM-OME
英文名称 SUBSTANCE P (7-11)
CAS 51165-05-0
分子式 C31H44N6O5S
分子量 612.78
MOL 文件 51165-05-0.mol
51165-05-0 结构式 51165-05-0 结构式

基本信息

中文别名
N-(1-AMINO-4-METHYLSULFANYL-1-OXOBUTAN-2-YL)-2-[[2-[[2-[(2-AMINO-3-PHENYLPROPANOYL)AMINO]-3-PHENYLPROPANOYL]AMINO]ACETYL]AMINO]-4-METHYLPENTANAMIDE
英文别名
FFGLM-NH2
PENTA-SUBSTANCE P
SUBSTANCE P (7-11)
Substance P 7-11(TFA)
PHE-PHE-GLY-LEU-MET-NH2
SUBSTANCE P FRAGMENT 7-11
H-PHE-PHE-GLY-LEU-MET-NH2
L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
SUBSTANCE P FRAGMENT 7-11 ACETATE)
L-Phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide

物理化学性质

沸点1003.3±65.0 °C(Predicted)
密度1?+-.0.06 g/cm3(Predicted)
储存条件-15°C
溶解度Soluble in DMSO
酸度系数(pKa)13.26±0.46(Predicted)
形态固体
颜色White to off-white

常见问题列表

生物活性
Substance P (7-11) 是神经肽物质P的C-末端片段,其可引起细胞内钙浓度的增加。
体外研究

Substance P (7-11) increases PGE2 and collagenase production at concentrations greater than 1 μM. Substance P (7-11), but not intact SP, SP-(1-4), SP-(1-6), SP- (8-11) or SP-(9-1 1), nor the tachykinins NKA and NKB, causes an increase in the intracellular calcium concentration as measured by the fluorescent dye Fura-2. The maximal change in intracellular calcium induced by 10 μM Substance P (7-11) was 140±30 nM.

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