90419-12-8
中文名称
ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2
英文名称
PANCREATIC POLYPEPTIDE, RAT
CAS
90419-12-8
分子式
C195H298N58O57S1
分子量
4398.87
更新日期
2024/07/07 16:59:16
基本信息
中文别名
胰脏多肽老鼠胰脏多肽
老鼠胰脏多肽, ≥95% (HPLC)
英文别名
PP, RATRat pancreatic polypeptide
PANCREATIC POLYPEPTIDE, RAT
Pancreatic polypeptide(rat) (9CI)
Pancreatic Polypeptide rat, ≥95% (HPLC)
APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY-NH2
Pancreatic Polypeptide ratPancreatic Polypepti
ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR
Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Tyr-NH2
ALA-PRO-LEU-GLU-PRO-MET-TYR-PRO-GLY-ASP-TYR-ALA-THR-HIS-GLU-GLN-ARG-ALA-GLN-TYR-GLU-THR-GLN-LEU-ARG-ARG-TYR-ILE-ASN-THR-LEU-THR-ARG-PRO-ARG-TYR-NH2
所属类别
生物：小分子化合物常见问题列表
生物活性
Pancreatic Polypeptide, rat 是神经肽 (NPY) 受体激动剂，对 NPYR4 有很高的亲和性。靶点
NPYR4
体外研究
Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic Polypeptide (1 μM) does not alter proliferation in BRIN BD11 or 1.1B4 beta-cells, but reverses the decreased cell viability in BRIN BD11 cells induced by streptozotocin. Pancreatic Polypeptide (0.1 nM-1 μM) shows no effect on insulin secretion from isolated mouse islets, and does not affect the membrane potential and (Ca 2+ ) i levels in BRIN BD11 cells at 1 μM.
体内研究
Pancreatic Polypeptide (25 nmol/kg bw, i.p.) reduces glucose-stimulated insulin concentrations but shows no effect on acute feeding behaviour in overnight fasted mice.