75976-10-2

中文名称人体胰脏多肽

英文名称 PANCREATIC POLYPEPTIDE, HUMAN

CAS 75976-10-2

分子式 C185H287N53O54S2

分子量 442.3

MOL 文件 75976-10-2.mol

更新日期 2024/07/29 19:53:32

75976-10-2 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

人胰腺多肽
人体胰脏多肽
人胰多肽 (HPP)
小鼠胰多肽ELISA试剂盒
人体胰脏多肽, ≥95% (HPLC)

英文别名

PP, HUMAN
PANCREATIC POLYPEPTIDE
Human pancreatic polypeptide
PANCREATIC POLYPEPTIDE, HUMAN
M.W. 4181.71 C185H287N53O54S2
Pancreatic polypeptide(human) (9CI)
PANCREATIC POLYPEPTIDE, HUMAN USP/EP/BP
APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2
Pancreatic Polypeptide human, ≥95% (HPLC)
Pancreatic Polypeptide huManPancreatic Polypeptide

所属类别

生物化工：多肽

物理化学性质

储存条件-15°C

溶解度Water: 1 mg/ml

形态粉末

颜色White to off-white

水溶解性Soluble to 0.70 mg/ml in water

常见问题列表

作用

人体胰脏多肽的作用包括胰腺分泌的抑制和胆囊的松弛。中枢给予的人体胰脏多肽产生通过局限于下丘脑和脑干的受体介导的进食的适度提高。

生理作用

人体胰脏多肽是由胰腺分泌的一种由36个氨基酸组成的多肽激素。人体胰脏多肽具有如下生理作用：(1)抑制胆囊收缩素和胰酶的排放，使胆囊平滑肌松弛，可降低胆囊内的压力，胆总管括约肌紧张加强，抑制胆汁向十二指肠的排放；(2)抑制餐后胰液和胆汁分泌，抑制胰泌素和胆囊收缩素等对胰腺分泌的促进作用；(3)在胃肠道中抑制五肽胃泌素引起的胃酸分泌；(4)抑制血浆胃动素的分泌，增加食管下括约肌的压力，抑制胃体部肌电活动。

生物活性

Pancreatic Polypeptide, human 是一种 C-末端酰胺化的含 36 个氨基酸的多肽，用作神经肽 Y (NPY) Y4/Y5 受体激动剂。

靶点

Neuropeptide Y (NPY) Y4/Y5 receptor

体外研究

Human pancreatic polypeptide (hPP) is one such peptide, being released postprandially from F cells of the pancreatic islets depending on caloric load, food consumption and circadian rhythm. It is a C-terminally amidated 36 amino acid peptide with a characteristic hairpin-like pancreatic polypeptide (PP)-fold and acts at the Y4 receptor to induce satiety and delay gastric emptying and motility. Addition of the human pancreatic polypeptide (hPP) (10 nM-1 μM) results in a significant, dose-dependent reduction in both basal and stimulated release. Human pancreatic polypeptide (hPP) can also inhibit basal and stimulated NPY release with a pharmacological profile suggesting a role for Y4 presynaptic receptors.