518-75-2
中文名称
桔霉素
英文名称
CITRININ
CAS
518-75-2
EINECS 编号
208-257-2
分子式
C13H14O5
MDL 编号
MFCD00006912
分子量
250.25
MOL 文件
518-75-2.mol
更新日期
2024/05/09 14:21:16
![518-75-2 结构式](/CAS/GIF/518-75-2.gif)
基本信息
中文别名
桔霉素橘霉素
桔青霉素
橘黴毒素
英文别名
4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC ACID
ANTIMYCIN
CIT
CITRININ
CITRININ, PENICILLIUM CITRINUM
(3r,4s)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carbox
(3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
,(3r-trans)-
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-
4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylicaci
6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-(3r-trans)-3h-2-benzopyran-7-carboxylicaci
8-Hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
Citriain
citrinin,antimycin
3,4-dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxobenzo(c)pyran-7-carboxylic acid
CITRININ FROM PENICILLIUM CITRINUM
Cytrinine
3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-
所属类别
原料药:其它抗生素类药物理化学性质
熔点175°C (dec.)
熔点175°C (dec.)
比旋光度D18 -37.4° (c = 1.15 in alc.)
沸点313.38°C (rough estimate)
密度1.37
折射率1.4560 (estimate)
闪点2℃
储存条件2-8°C
储存条件2-8°C
溶解度≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
酸度系数(pKa)1.52±0.60(Predicted)
形态结晶粉末或薄片
颜色黄色
Merck13,2351
BRN5282243
稳定性吸湿性
(IARC)致癌物分类3 (Vol. 40, Sup 7) 1987
EPA化学物质信息Citrinin (518-75-2)
安全数据
警示词危险
危险性描述H301+H311+H331-H351
危险品标志T
危险类别码23/24/25-40-36/37/38
危险类别码R23/24/25-R40
危险品运输编号UN 3462 6.1/PG 3
危险品运输编号UN 3462 6.1/PG 3
WGK Germany3
WGK Germany3
RTECS号DJ2275000
危险等级6.1(a)
包装类别II
海关编码29419090
毒性LD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)
应用领域
用途一
一种真菌毒素,发现于谷物和使动物肾中毒的饲料中,是啮齿类动物的制畸剂,该毒素能减少胚泡细胞数量、胚胎存活率、减轻新生儿体重及增加致命的畸形。在培养基中对细胞的毒性和活性氧的类别有关。激活线粒体的凋亡路径,阻碍抗凋亡磷酸化路径。