57-41-0
![57-41-0 结构式](/CAS/GIF/57-41-0.gif)
基本信息
苯妥英
5,5-二苯基乙内酰脲
5,5-联苯基乙内酰脲
二苯基乙內醯脲
二苯尿囊素
5,5-DIPHENYLHYDANTHOIN
5,5-DIPHENYLHYDANTOIN
DIPHENYLHYDANTOIN
LABOTEST-BB LT00159593
PHENYTION
PHENYTOIN
PHENYTOIN BASE
2,4-Imidazolidinedione, 5,5-diphenyl-
5,5-diphenyl-hydantoi
5,5-Diphenylimidazolidin-2,4-dione
5,5-Dwufenylohydantoina
Aleviatin
Antisacer
Causoin
Citrullamon
Citrulliamon
Comital
Comitoina
component of Mebroin
物理化学性质
安全数据
常见问题列表
苯妥英是一种抗癫痫药,用于治疗多种癫痫发作。它也是一种Vaughan-WilliamsⅠB类抗心律失常药,但目前极少用于治疗心律失常。
苯妥英常见副作用包含恶心、胃痛、缺乏食欲、肢体协调不良、毛发增长,以及牙龈增生。其他可能的严重副作用则包含嗜睡、自残、肝脏问题、骨髓抑制、低血压,以及毒性表皮溶解症。
Target | Value |
Sodium channel |
Phenytoin is an antiepileptic drug. It is useful to partial seizures and generalized tonic-clonic seizures but not primary generalized seizures such as absence seizures or myoclonic seizures. Phenytoin is believed to protect against seizures by causing voltage-dependent block of voltage-gated sodium channels.
Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials.
When neurons are depolarized and the channels transition into the open and inactivated states, greater binding and block occur. The inhibitory potency is strongly use dependent, so that block accumulates with prolonged or repetitive activation, such as occurs during a seizure discharge. The blocking of sodium channels by phenytoin is of slow onset. The time course of fast sodium currents is therefore not altered in the presence of the drug and action potentials evoked by synaptic depolarizations of ordinary duration are not blocked. Thus phenytoin is able to selectively inhibit pathological hyperexcitability in epilepsy without unduly impairing ongoing activity. Phenytoin also blocks persistent sodium current and this may be of particular importance in seizure control. Phenytoin is a class 1b antiarrhythmic.
Phenytoin (5,5-Diphenylhydantoin; 60 mg/kg; daily; 28 days ) reduces tumour growth in six week-old female Rag2 -/- Il2rg -/- mice with MDA-MB-231 cells.
知名试剂公司产品信息
5,5-Diphenylhydantoin, 99+%(57-41-0)