72803-02-2
中文名称
达罗地平
英文名称
Darodipine
CAS
72803-02-2
分子式
C19H21N3O5
分子量
371.39
MOL 文件
72803-02-2.mol
更新日期
2023/02/09 13:42:07
72803-02-2 结构式
基本信息
中文别名
达罗地平 英文别名
PY-108068PY-108063
PY-108-068
Darodipine
Darodipine(PY-108068)
4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
所属类别
生物化工：生化试剂
常见问题列表
生物活性
Darodipine (PY 108-068, PY-108068) 是有效地钙离子通道 (calcium chanel) 拮抗剂。体内研究
Treatment with darodipine increases the number and the average length of alkaline phosphatase-reactive capillaries and reduces the intercapillary distance and the diameter of cerebral capillaries in old rats. The pericapillary microrenvironment of the Ammon’s horn is the most sensitive to treatment with darodipine. Darodipine may reduce neuronal cytoskeletal changes occurring in aging and in neurodegenerative disorders. A 6-month treatment (from the 18th to the 24th month of life) with an oral daily dose of 10 mg/kg of darodipine restores in part the expression of 200 kDa-NF subunit immunoreactivity in the cerebellar cortex.