764-22-7
中文名称
D-赤式-C 18 - 二氢-D-神经鞘氨醇
英文名称
D-erythro-C18-Dihydro-D-sphingosine
CAS
764-22-7
分子式
C18H39NO2
分子量
301.51
MOL 文件
764-22-7.mol
764-22-7 结构式
基本信息
中文别名
D-赤式-C 18 - 二氢-D-神经鞘氨醇 英文别名
(2S,3R)-SPC-102860
SPHINGANINE
Sphinganine (d18:0)
D-erythro-sphinganine
Dihydro-D-erythro-Sphingosine
D-ERYTHRO-DIHYDRO-D-SPHINGOSINE
(2S,3R)-2-aminooctadecane-1,3-diol
D-erythro-C18-Dihydro-D-sphingosine
(2S,3R)-2-azanyloctadecane-1,3-diol
所属类别
生物化工：生化试剂物理化学性质
熔点70-72°C
沸点446.2±25.0 °C(Predicted)
密度0.927±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度在DMSO中的溶解度为25mg/mL（温热）
酸度系数(pKa)12.57±0.45(Predicted)
形态白色至类白色固体
颜色白色
稳定性可在-20°下的DMSO或乙醇溶液保存长达1个月。
常见问题列表
生物活性
D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。靶点
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Human Endogenous Metabolite
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体外研究
D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na 3 VO 4 -, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [ 3 H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA 2 α activity.