78123-71-4
![78123-71-4 结构式](/CAS/GIF/78123-71-4.gif)
基本信息
L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺
DAMGO
Dagol
Damge
DAMPGO
RX-783006
NIH 10891
M.W. 513.59 C26H35N5O6
Tyr-D-Ala-Gly-MePhe-Gly-ol
H-Tyr-D-Ala(Me)Phe-NH-CH2-OH
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-P0210 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 DAMGO | 78123-71-4 | 1mg | 600元 |
2024/08/19 | HY-P0210 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 DAMGO | 78123-71-4 | 5mg | 990元 |
2024/08/19 | HY-P0210 | L-酪氨酰-D-丙氨酰甘氨酰-N-(2-羟基乙基)-NALPHA-甲基-L-苯丙氨酰胺 DAMGO | 78123-71-4 | 10mg | 1700元 |
常见问题列表
Kd: 3.46±0.84 nM (native μ-OPR)
DAMGO, a μ-opioid receptor selective agonist, distinguishes between μ- and δ-opioid receptors around their first extracellular loops. In native μ-OPR, the K d value for DAMGO is 3.46± 0.84 nM (n=3). The chimeric receptor MMDD, in which the carboxy-terminal half of μ-OPR is replaced with the corresponding region of δ-OPR, exhibits an equivalent affinity (K d =2.13±0.40 nM; n=3) to DAMGO compared with the native μ-OPR. DAMGO is a selective μ-opioid peptide. DAMGO abolishes the neuroprotective effect of CXCL12 in N-methyl-d-aspartate (NMDA) neurotoxicity studies. Regulation of neuronal response to CXCL12 is essential for shaping of developing and mature central nervous system (CNS). To establish whether DAMGO alter the effect of CXCL12 on neuronal survival, the ability of CXCL12 to protect neurons from N-methyl-d-aspartate (NMDA)-induced death is examined in the presence and absence of DAMGO. Cortical cultures are treated with DAMGO (1 and 10 μM). Neurons are subsequently exposed to NMDA (20 min) and/or CXCL12 (added 10 min before NMDA) in the absence of glia and then returned to the original culture dishes with the glial feeder layer. Neuronal death is evaluated after 24 h. DAMGO inhibits neuronal survival promoted by CXCL12.