80734-02-7
中文名称
盐酸仑氨西林
英文名称
LENAMPICILLIN HYDROCHLORIDE
CAS
80734-02-7
分子式
C21H23N3O7S
分子量
461.49
MOL 文件
80734-02-7.mol
80734-02-7 结构式
基本信息
中文别名
化合物 T15734 英文别名
kb1585kbt1585
kbt-1585
varacillin
takacillin
LENAMPICILLIN
LenampicillinHCl
KBT-1585 HYDROCHLORIDE
Lempicillin hydrochloride
Lenanpicillin hydrochloride
所属类别
有机原料：羧酸类化合物及衍生物物理化学性质
熔点145° (dec)
储存条件Store at -20°C, sealed storage, away from moisture and light
溶解度DMSO:100.0(Max Conc. mg/mL);200.82(Max Conc. mM)
形态Solid
颜色White to off-white
安全数据
毒性LD50 in male, female rats, male, female mice (mg/kg): approx 10000, approx 10000, 8294, 8492 orally; 4362, 4471, 3576, 4284 s.c.; 876, 838, 711, 775 i.v.; in dogs (mg/kg): >300 orally (Ogino)
盐酸仑氨西林价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/11/08 | HY-100500 | 盐酸仑氨西林 Lenampicillin hydrochloride | 80734-02-7 | 5mg | 2800元 |
| 2024/11/08 | HY-100500 | 盐酸仑氨西林 Lenampicillin hydrochloride | 80734-02-7 | 10mg | 4800元 |
常见问题列表
生物活性
Lenampicillin hydrochloride (KBT 1585 hydrochloride) 是氨苄西林的口服前药，是一种有效的-内酰胺类抗菌(beta-lactam antibacterial) 剂，可抑制细菌的青霉素结合蛋白(转肽酶)。与氨苄西林相比，Lenampicillin 有改善吸收、减少副作用的作用，并应用于化脓性皮肤软组织感染的研究。靶点
IC50: bacterial penicillin-binding proteins (transpeptidase)
体内研究
Lenampicillin hydrochloride (KBT-1585) (oral adminstration; 0-1000 mg/kg) does not lead to death in dogs, and maximum dose of in this acute toxicity study is recorded because of causing emesis.Lenampicillin hydrochloride (LAPC) are identified for it main metabolites in rat and dogs. The main metabolite in peripheral plasma is 2,3-butanediol in rats and dog, On the other hand, high levels of acetoin is found in portal plasma for early period after dosing of LAPC. These results shows that the biotransformation of promoiety in LAPC to acetoin carried out mainly in intestinal tissues, but acetoin is converted to 2,3-butanediol in liver.