899452-51-8
中文名称
双砜琥珀酰亚胺酯
英文名称
4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid-N-hydroxy succinimidyl ester
CAS
899452-51-8
分子式
C29H27NO9S2
分子量
597.66
MOL 文件
899452-51-8.mol
899452-51-8 结构式
基本信息
中文别名
双砜活性酯双砜琥珀酰亚胺酯
2,5-二氧代吡咯烷-1-基 4-(3-对甲苯磺酰基-2-(对甲苯磺酰基甲基)丙酰基)苯甲酸酯
英文别名
Bis-sulfone SEBis–sulfone NHS Ester
2,5-Dioxopyrrolidin-1-yl 4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoate
4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid-N-hydroxy succinimidyl ester
所属类别
医药中间体：原料药中间体
应用领域
用途一
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.