98717-15-8
98717-15-8 结构式
基本信息
N-(2,6-二甲基苯基)-1-正丙基哌啶-2-甲酰胺盐酸盐
盐酸罗哌卡因
S—盐酸罗哌卡因
罗哌卡因(盐酸或甲磺盐)
甲磺酸罗哌卡因
盐酸罗派卡因
盐酸罗哌卡因
ROPIVACAINE HCL
ROPIVACAINE HYDROCHLORIDE
ROPIVCACAINE HYDROCHLORIDE
(s)-n-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
S-ROPIVACAINE HCL
(S)-ROPIVACAINE HYDROCHLORIDE
Ropivacaine mesilate
Ropivacaine hydrochloride
物理化学性质
常见问题列表
高浓度时, 布吡卡因对A类和C类神经纤维的复合动作电位的抑制作用分别比盐酸罗派卡因强16%和3%,表明盐酸罗派卡因和布吡卡因的感觉阻滞作用类似,但盐酸罗派卡因的运动阻滞作用弱。低浓度时, 盐酸罗派卡因主要阻滞感觉神经纤维,对运动神经纤维的阻滞轻,即盐酸罗派卡因具有高度的感觉与运动神经阻滞分离的特性,对术后硬膜外镇痛有独特的优点。
IC50: sodium ion influxIC50: 402.7 μM (TREK-1 in COS-7 cell's membrane)
Epidural administration of Ropivacaine hydrochloride effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.
Ropivacaine hydrochloride inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).
Ropivacaine hydrochloride prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.
Ropivacaine hydrochloride inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs.
| Animal Model: | Adult Sprague-Dawley rats (300–400g) |
| Dosage: | 1 μM |
| Administration: | Infusion (added to the perfusate reservoir) |
| Result: | Attenuated pressure-dependent increases in filtration coefficient (K f ). |