苯呋洛尔
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- CAS号:
- 39552-01-7
- 英文名:
- Befunolol
- 英文别名:
- Befunolol;Befunolol USP/EP/BP;(±)Befunolol,(±) Befunolol;2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran;2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;(-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;(+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone;ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl;7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone
- 中文名:
- 苯呋洛尔
- 中文别名:
- 苯呋洛尔;氧茚心安;化合物 T13982;(±)-BEFUNOLOL;2-乙酰-7-(2-羟基-3-异丙胺丙氧)-苯并呋喃;1-[7-[2-羟基-2-3-[(1-甲基乙基)氨基]丙氧基]-2-苯并呋喃基]乙酮
- CBNumber:
- CB01116973
- 分子式:
- C16H21NO4
- 分子量:
- 291.34
- MOL File:
- 39552-01-7.mol
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苯呋洛尔化学性质
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熔点:
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115°
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沸点:
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433.35°C (rough estimate)
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密度:
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1.1049 (rough estimate)
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折射率:
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1.5500 (estimate)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Chloroform (Slightly), DMSO (Slightly, Heated)
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形态:
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Solid
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颜色:
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White to Off-White
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CAS 数据库:
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39552-01-7
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苯呋洛尔性质、用途与生产工艺
(±)-Befunolol 是一种 β-肾上腺素能受体阻断剂。
A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites.
化学性质
结晶。熔点115℃。苯呋洛尔盐酸盐(C16H21NO4·HCI),熔点163℃。
用途
该品属β-肾上腺素功能阻滞剂。可治疗青光眼。小鼠静脉注射LD50为100-105mg/kg。
生产方法
由2-乙酰-7-羟基苯并呋喃与3-氯-1,2-环氧丙烷反应后再与异丙胺作用而得。取8.8g2-乙酰-7-羟基苯并呋喃中,加入80ml3-氯-1,2-环氧丙烷和0.2g盐酸哌啶。将混合物加热至105℃,反应3h。反应后蒸发出过量的3-氯-1,2-环氧丙烷。生成物在减压下蒸馏,得9.3g2-乙酰-7-(2,3-环氧丙氧)苯并呋喃,沸点175-176℃(93Pa)。取6g上述生成物溶于30ml乙醇中,加10ml异丙胺,混合物回流40min,由反应混合物中蒸除溶剂,得到的残余物用环己烷-丙酮重结晶,得6g苯呋洛尔。
苯呋洛尔
上下游产品信息
上游原料
下游产品
39552-01-7, 苯呋洛尔 相关搜索:
- Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- 氧茚心安
- 化合物 T13982
- (±)-BEFUNOLOL
- 1-[7-[2-羟基-2-3-[(1-甲基乙基)氨基]丙氧基]-2-苯并呋喃基]乙酮
- 苯呋洛尔
- 2-乙酰-7-(2-羟基-3-异丙胺丙氧)-苯并呋喃
- 39552-01-7
- (±)Befunolol,(±) Befunolol
- Befunolol USP/EP/BP
- (+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran
- (-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran
- ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl
- 7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone
- 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone
- Ethanone, 1-[7-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2-benzofuranyl]-
- 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran
- Befunolol
- 2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran
- 1-[7-[2-Hydroxy-3-[(1-methylethyl)-amino]propoxy]-2-benzofuranyl]ethanone
- 1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)ethanone
- 1-(7-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2-benzofuranyl)-ethanon