网站主页 >> CAS数据库列表 >> Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
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- CAS号:
- 109351-33-9
- 英文名:
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
- 英文别名:
- (S)-Terazosin;(S) Terazosin,(S)Terazosin;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2S)-tetrahydro-2-furanyl]-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-tetrahydro-2-furanyl]carbonyl]- (9CI)
- 中文名:
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
- 中文别名:
- (S)-特拉唑嗪;化合物 T12815;(S)-TERAZOSIN
- CBNumber:
- CB01270413
- 分子式:
- C19H25N5O4
- 分子量:
- 387.43
- MOL File:
- 109351-33-9.mol
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Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-化学性质
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沸点:
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664.5±65.0 °C(Predicted)
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密度:
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1.332±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 150 mg/mL (387.17 mM)
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酸度系数(pKa):
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6.52±0.50(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-性质、用途与生产工艺
(S)-Terazosin 是 Terazosin 的有活性的 S 型异构体,也是一种有效的,高亲和力的 α-肾上腺素受体拮抗剂,对 α1a,α1b 和 α1d-肾上腺素受体的 Ki 值分别为 3.91 nM,0.79 nM 和 1.16 nM。(S)-Terazosin 对 α2a,α2B 和 α2c-肾上腺素受体也具有高亲和力,Ki 值分别为 729 nM,3.5 nM 和 46.4 nM。
Ki: 3.91 nM (α1a-adrenoceptor), 0.79 nM (α1b-adrenoceptor) and 1.16 nM (α1d-adrenoceptor); 729 nM (α2a-adrenoceptor), 3.5 nM (α2Ba-adrenoceptor) and 46.4 nM (α2c-adrenoceptor)
The racemic compound and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors with K
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values in the low nanomolar range, and showed potent antagonism of α1-adrenoceptors in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate.
(S)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 6.93. (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively.
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-B0371D | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- (S)-Terazosin | 109351-33-9 | 5mg | 2000元 |
2024/04/30 | HY-B0371D | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- (S)-Terazosin | 109351-33-9 | 10mM * 1mLin DMSO | 2200元 |
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
生产厂家
109351-33-9, Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- 相关搜索:
- 化合物 T12815
- (S)-特拉唑嗪
- (S)-TERAZOSIN
- 109351-33-9
- Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2S)-tetrahydro-2-furanyl]-
- (S) Terazosin,(S)Terazosin
- (S)-Terazosin
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-tetrahydro-2-furanyl]carbonyl]- (9CI)
- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-