Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-
中文名称 | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- |
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中文同义词 | (S)-TERAZOSIN;(S)-特拉唑嗪;化合物 T12815 |
英文名称 | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- |
英文同义词 | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2S)-tetrahydro-2-furanyl]carbonyl]- (9CI);(S)-Terazosin;(S) Terazosin,(S)Terazosin;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2S)-tetrahydro-2-furanyl]- |
CAS号 | 109351-33-9 |
分子式 | C19H25N5O4 |
分子量 | 387.43 |
EINECS号 | |
相关类别 | |
Mol文件 | 109351-33-9.mol |
结构式 | ![]() |
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- 性质
沸点 | 664.5±65.0 °C(Predicted) |
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密度 | 1.332±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:150 mg/ml(387.17 mM) |
酸度系数(pKa) | 6.52±0.50(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- 用途与合成方法
Ki: 3.91 nM (α1a-adrenoceptor), 0.79 nM (α1b-adrenoceptor) and 1.16 nM (α1d-adrenoceptor); 729 nM (α2a-adrenoceptor), 3.5 nM (α2Ba-adrenoceptor) and 46.4 nM (α2c-adrenoceptor)
The racemic compound and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors with K i values in the low nanomolar range, and showed potent antagonism of α1-adrenoceptors in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate.
(S)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 6.93. (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B0371D | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- (S)-Terazosin | 109351-33-9 | 5mg | 2000元 |
2024/08/19 | HY-B0371D | Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (S)- (S)-Terazosin | 109351-33-9 | 10mM * 1mLin DMSO | 2200元 |