GW 1100
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- CAS号:
- 306974-70-9
- 英文名:
- GW-1100
- 英文别名:
- GW-1100;GW1100;GW1100;GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem;1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone;Benzoic acid, 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-, ethyl ester
- 中文名:
- GW 1100
- 中文别名:
- 1-(4-乙氧羰基苯基)-2-(4-氟苄基硫基)-5-(2-乙氧基-5-嘧啶基甲基)-4-嘧啶酮;4-[5-[(2-乙氧基-5-嘧啶)甲基]-2-[[(4-氟苯基)甲基]硫代]-4-氧代-1(4H)-嘧啶]-苯甲酸乙酯
- CBNumber:
- CB01872299
- 分子式:
- C27H25FN4O4S
- 分子量:
- 520.58
- MOL File:
- 306974-70-9.mol
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GW 1100化学性质
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熔点:
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208-210℃
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沸点:
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690.2±65.0 °C(Predicted)
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密度:
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1.29±0.1 g/cm3(Predicted)
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储存条件:
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+2C to +8C
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溶解度:
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Soluble in DMSO (up to 2 mg/ml) or in DMF (up to 5 mg/ml).
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形态:
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White powder
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酸度系数(pKa):
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1.20±0.22(Predicted)
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颜色:
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White
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. Dilutions into aqueous media are not stable and should be used within one working day.
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GW 1100性质、用途与生产工艺
GW-1100是选择性的 GPR40 拮抗剂，pIC50为6.9。
GW-1100 (GW1100) dose dependently inhibits GPR40-mediated Ca
2+
elevations stimulated by GW9508 and linoleic acid (pIC
50
values of 5.99±0.03 and 5.99±0.06, respectively). GW-1100 at a concentration of 1 μM produces a significant rightward shift in the concentration-response curve to GW9508 (pEC
50
=7.17±0.08 in the absence and pEC
50
=6.79±0.09 in the presence of 1 μM GW-1100; P<0.05; n=3). At concentrations of GW-1100 of 3 μM and higher a significant decrease in the maximal response is observed with a continuing rightward shift in the pEC
50
response. GW-1100 (GW1100) reduces FFAR1 ligand-induced intracellular calcium in CHO-K1/bFFAR1 cells and neutrophils. CHO-K1/bFFAR1 cells are incubated for 15 min with 10 μM GW1100 or vehicle (0.1% DMSO) and then stimulated with vehicle, oleic acid, linoleic acid or GW9508. GW-1100 significantly reduces the increase in intracellular calcium induced by 300 μM oleic acid (AUC
(60-150 s)
, p<0.05), 100 μM linoleic acid (AUC
(60-150 s)
, p<0.05) and 10 μM GW9508 (AUC
(60-150 s)
, p<0.05).
The intracerebroventricular injection of DHA (50 µg) and GW9508 (1.0 µg), a GPR40-selective agonist, significantly reduces mechanical allodynia and thermal hyperalgesia at day 7, but not at day 1, after CFA injection. These effects are inhibited by intracerebroventricular pretreatment with GW-1100 (10 µg), a GPR40 antagonist.
GW 1100
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-50691 | GW-1100 | | 1 mg | 249元 |
| 2024/04/30 | HY-50691 | 4-[5-[(2-乙氧基-5-嘧啶)甲基]-2-[[(4-氟苯基)甲基]硫代]-4-氧代-1(4H)-嘧啶]-苯甲酸乙酯
GW-1100 | 306974-70-9 | 5mg | 549元 |
306974-70-9, GW 1100 相关搜索:
- Heterocycles
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- G蛋白偶联受体&G蛋白
- 1-(4-乙氧羰基苯基)-2-(4-氟苄基硫基)-5-(2-乙氧基-5-嘧啶基甲基)-4-嘧啶酮
- 4-[5-[(2-乙氧基-5-嘧啶)甲基]-2-[[(4-氟苯基)甲基]硫代]-4-氧代-1(4H)-嘧啶]-苯甲酸乙酯
- 306974-70-9
- GW1100;GW1100
- GPR40 Antagonist, GW1100 - CAS 306974-70-9 - Calbiochem
- 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone
- GW-1100
- Benzoic acid, 4-[5-[(2-ethoxy-5-pyrimidinyl)methyl]-2-[[(4-fluorophenyl)methyl]thio]-4-oxo-1(4H)-pyrimidinyl]-, ethyl ester