R(+)-3-氨基-1-羟基-2-吡咯烷酮
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- CAS号:
- 123931-04-4
- 英文名:
- (R)-(+)-HA-966
- 英文别名:
- (+)-HA-966;HA966-001-R;Zinc03791818;(R)-(+)-HA-966;(R)(+)HA966,(R) (+) HA 966;R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)-
- 中文名:
- R(+)-3-氨基-1-羟基-2-吡咯烷酮
- 中文别名:
- 化合物 T12637;HA966标准品1-R;(R) -3-氨基-1-羟基吡咯烷-2-酮;(3R)-3-氨基-1-羟基-2-吡咯烷酮;R(+)-3-氨基-1-羟基-2-吡咯烷酮
- CBNumber:
- CB0190556
- 分子式:
- C4H8N2O2
- 分子量:
- 116.12
- MOL File:
- 123931-04-4.mol
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R(+)-3-氨基-1-羟基-2-吡咯烷酮化学性质
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熔点:
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166℃
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沸点:
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258.6±50.0 °C(Predicted)
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密度:
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1.436±0.06 g/cm3(Predicted)
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储存条件:
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Desiccate at RT
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溶解度:
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H2O: soluble
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酸度系数(pKa):
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7.19±0.20(Predicted)
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形态:
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solid
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颜色:
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white
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旋光性 (optical activity):
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[α]22/D +103°, c = 1 in H2O(lit.)
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水溶解性:
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Soluble to 100 mM in water
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R(+)-3-氨基-1-羟基-2-吡咯烷酮性质、用途与生产工艺
(R)-(+)-HA-966 ((+)-HA-966) 是 N-甲基-D-天冬氨酸 (NMDA) 受体复合物的甘氨酸位点的部分激动剂/拮抗剂。(R)-(+)-HA-966 通过苯丙胺选择性阻断中脑边缘多巴胺系统的活化。(R)-(+)-HA-966 可透过血脑屏障，有用于神经性和急性疼痛的潜力。
glycine site of the NMDA receptor
(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.).
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g).
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Animal Model:
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Sprague-Dawley rats (11 to 12 weeks old)
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Dosage:
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10 mg/kg
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Administration:
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IV
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Result:
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Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.
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R(+)-3-氨基-1-羟基-2-吡咯烷酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-100822 | (R)-(+)-HA-966 | | 5 mg | 1700元 |
| 2024/04/30 | HY-100822 | (R)-(+)-HA-966 | | 10 mM * 1 mLin DMSO | 1870元 |
R(+)-3-氨基-1-羟基-2-吡咯烷酮
生产厂家
123931-04-4, R(+)-3-氨基-1-羟基-2-吡咯烷酮 相关搜索:
- Glutamate receptor
- 标准品
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Ligand-Gated Ion Channels
- Ionotropic Glutamate Receptor Modulators
- Ion Channels
- (R) -3-氨基-1-羟基吡咯烷-2-酮
- HA966标准品1-R
- 化合物 T12637
- (3R)-3-氨基-1-羟基-2-吡咯烷酮
- R(+)-3-氨基-1-羟基-2-吡咯烷酮
- 123931-04-4
- (R)(+)HA966,(R) (+) HA 966
- HA966-001-R
- (+)-HA-966
- 2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)-
- (R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate
- (3R)-3-Amino-1-hydroxy-2-pyrrolidinone
- Zinc03791818
- (R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE
- R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE
- (R)-(+)-HA-966
- R(+)-HA-966 R(+)-3-AMINO-1-HYDROX