R(+)-3-氨基-1-羟基-2-吡咯烷酮
| 中文名称 | R(+)-3-氨基-1-羟基-2-吡咯烷酮 |
|---|---|
| 中文同义词 | R(+)-3-氨基-1-羟基-2-吡咯烷酮;(3R)-3-氨基-1-羟基-2-吡咯烷酮;化合物 T12637;HA966标准品1-R;(R) -3-氨基-1-羟基吡咯烷-2-酮 |
| 英文名称 | (R)-(+)-HA-966 |
| 英文同义词 | R(+)-HA-966 R(+)-3-AMINO-1-HYDROX;(R)-(+)-HA-966;R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE;(R)-(+)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE;Zinc03791818;(3R)-3-Amino-1-hydroxy-2-pyrrolidinone;(R)-3-amino-1-hydroxypyrrolidin-2-one 2,2,2-trifluoroacetate;2-Pyrrolidinone, 3-amino-1-hydroxy-, (3R)- |
| CAS号 | 123931-04-4 |
| 分子式 | C4H8N2O2 |
| 分子量 | 116.12 |
| EINECS号 | |
| 相关类别 | 标准品;Glutamate receptor |
| Mol文件 | 123931-04-4.mol |
| 结构式 |  |
R(+)-3-氨基-1-羟基-2-吡咯烷酮 性质
| 熔点 | 166℃ |
|---|---|
| 沸点 | 258.6±50.0 °C(Predicted) |
| 密度 | 1.436±0.06 g/cm3(Predicted) |
| 储存条件 | Desiccate at RT |
| 溶解度 | 可溶于水中 |
| 酸度系数(pKa) | 7.19±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色 |
| 旋光性 (optical activity) | [α]22/D +103°, c = 1 in H2O(lit.) |
| 水溶解性 | Soluble to 100 mM in water |
(R)-(+)-HA-966 ((+)-HA-966) 是 N-甲基-D-天冬氨酸 (NMDA) 受体复合物的甘氨酸位点的部分激动剂/拮抗剂。(R)-(+)-HA-966 通过苯丙胺选择性阻断中脑边缘多巴胺系统的活化。(R)-(+)-HA-966 可透过血脑屏障，有用于神经性和急性疼痛的潜力。
glycine site of the NMDA receptor
(R)-(+)-HA-966 ((+)-HA-966; 10 mg/kg; IV) significantly attenuates the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA (125, 250, 500, and 1000 mg/kg; i.v.).
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g).
| Animal Model: | Sprague-Dawley rats (11 to 12 weeks old) |
| Dosage: | 10 mg/kg |
| Administration: | IV |
| Result: | Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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