化合物 T16445
|
|
|
- CAS号:
- 154130-99-1
- 英文名:
- 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- 英文别名:
- PD 144418;PD 144418 OXALATE;Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-;1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- 中文名:
- 化合物 T16445
- 中文别名:
- 化合物 T16445
- CBNumber:
- CB02446510
- 分子式:
- C18H22N2O
- 分子量:
- 282.38
- MOL File:
- 154130-99-1.mol
|
|
|
化合物 T16445化学性质
-
沸点:
-
453.2±45.0 °C(Predicted)
-
|
-
密度:
-
1.067±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Desiccate at RT
-
|
-
溶解度:
-
<18.62mg/ml in DMSO
-
|
-
形态:
-
solid
-
|
-
酸度系数(pKa):
-
8.10±0.40(Predicted)
-
|
-
颜色:
-
Off-white
-
|
化合物 T16445性质、用途与生产工艺
PD 144418 是一种高亲和力，强效和选择性的 sigma 1 受体 (σ1 receptor) 配体 (对 σ1 和 σ2 的 Ki 值分别为 0.08 nM 和 1377 nM)，对其他受体，离子通道和酶没有任何显着的亲和力。PD 144418 具有潜在的抗精神病活性。
Ki: 0.08 nM (σ1 receptor) and 1377 nM (σ2 receptor)
In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis.
PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED
50
values of 7.0 mg/kg i.p..
|
Animal Model:
|
Male CD-1 mice induced with Mescaline
|
|
Dosage:
|
10 mg/kg
|
|
Administration:
|
Intraperitoneal injection
|
|
Result:
|
Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.
|
用途
PD 144418 is high affinity, selective 蟽1 ligand (Ki values are 0.08 and 1377 nM for 蟽1 and 蟽2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels
and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration.
化合物 T16445
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-108512 | 化合物 T16445
PD 144418 | 154130-99-1 | 2mg | 1800元 |
| 2024/08/19 | HY-108512 | PD 144418 | | 5 mg | 3200元 |
154130-99-1, 化合物 T16445 相关搜索:
- Pharmaceuticals
- Pfizer Compounds
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Amines
- C18H22N2OC2H2O4
- 化合物 T16445
- 154130-99-1
- Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-
- PD 144418
- 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- PD 144418 OXALATE