化合物 T16445
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- CAS号:
- 154130-99-1
- 英文名:
- 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- 英文别名:
- PD 144418;PD 144418 OXALATE;Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-;1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- 中文名:
- 化合物 T16445
- 中文别名:
- 化合物 T16445
- CBNumber:
- CB02446510
- 分子式:
- C18H22N2O
- 分子量:
- 282.38
- MOL File:
- 154130-99-1.mol
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化合物 T16445化学性质
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沸点:
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453.2±45.0 °C(Predicted)
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密度:
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1.067±0.06 g/cm3(Predicted)
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储存条件:
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Desiccate at RT
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溶解度:
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<18.62mg/ml in DMSO
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形态:
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solid
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酸度系数(pKa):
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8.10±0.40(Predicted)
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颜色:
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Off-white
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化合物 T16445性质、用途与生产工艺
PD 144418 是一种高亲和力,强效和选择性的 sigma 1 受体 (σ1 receptor) 配体 (对 σ1 和 σ2 的 Ki 值分别为 0.08 nM 和 1377 nM),对其他受体,离子通道和酶没有任何显着的亲和力。PD 144418 具有潜在的抗精神病活性。
Ki: 0.08 nM (σ1 receptor) and 1377 nM (σ2 receptor)
In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis.
PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED
50
values of 7.0 mg/kg i.p..
Animal Model:
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Male CD-1 mice induced with Mescaline
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Dosage:
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10 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity.
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用途
PD 144418 is high affinity, selective 蟽1 ligand (Ki values are 0.08 and 1377 nM for 蟽1 and 蟽2 respectively). PD 144418 displays no significant activity at a wide range of other receptors, ion channels
and enzymes. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration.
化合物 T16445
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-108512 | 化合物 T16445 PD 144418 | 154130-99-1 | 2mg | 1800元 |
2024/08/19 | HY-108512 | PD 144418 | | 5 mg | 3200元 |
154130-99-1, 化合物 T16445 相关搜索:
- Pharmaceuticals
- Pfizer Compounds
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- Amines
- C18H22N2OC2H2O4
- 化合物 T16445
- 154130-99-1
- Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl-
- PD 144418
- 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE
- PD 144418 OXALATE