化合物 T16445
中文名称 | 化合物 T16445 |
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中文同义词 | 化合物 T16445 |
英文名称 | 1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE |
英文同义词 | PD 144418 OXALATE;1,2,3,6-TETRAHYDRO-5-[3-(4-METHYLPHENYL)-5-ISOXAZOLYL]-1-PROPYLPYRIDINE OXALATE;PD 144418;Pyridine,1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propyl- |
CAS号 | 154130-99-1 |
分子式 | C18H22N2O |
分子量 | 282.38 |
EINECS号 | |
相关类别 | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals |
Mol文件 | 154130-99-1.mol |
结构式 |
化合物 T16445 性质
沸点 | 453.2±45.0 °C(Predicted) |
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密度 | 1.067±0.06 g/cm3(Predicted) |
储存条件 | Desiccate at RT |
溶解度 | <18.62mg/ml,溶于 DMSO |
形态 | 固体 |
酸度系数(pKa) | 8.10±0.40(Predicted) |
颜色 | 米白色 |
Ki: 0.08 nM (σ1 receptor) and 1377 nM (σ2 receptor)
In vitro, PD 144418 reverses the N-methyl-D-aspartate (NMDA)-induced increase in cyclic GMP (cGMP) in rat cerebellar slices without affecting the basal levels, suggesting that σ1 sites may be important in the regulation of glutamine-induced actions. PD 144418 potentiates the decrease in 5-hydroxytryptophan caused by Haloperidol in the mesolimbic region, but by itself has no effect in 5-HT and dopamine (DA) synthesis.
PD 144418 (10 mg/kg; intraperitoneal injection; male CD-1 mice) treatment antagonizes Mescaline-induced scratching at doses that did not alter spontaneous motor activity, with PD 144418 showing ED 50 values of 7.0 mg/kg i.p..
Animal Model: | Male CD-1 mice induced with Mescaline |
Dosage: | 10 mg/kg |
Administration: | Intraperitoneal injection |
Result: | Antagonized mescaline-induced scratching at doses that did not alter spontaneous motor activity. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-108512 | 化合物 T16445 PD 144418 | 154130-99-1 | 2mg | 1800元 |
2024/08/19 | HY-108512 | PD 144418 | 5 mg | 3200元 |