4-乙炔基-L-苯丙氨酸 HCL
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- CAS号:
- 278605-15-5
- 英文名:
- 4-Ethynyl-L-phenylalanine HCl
- 英文别名:
- 4-Ethynylphenylalanine;4-Ethynyl-L-phenylalanine;L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;pEthynylphenylalanine,p Ethynylphenylalanine;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid
- 中文名:
- 4-乙炔基-L-苯丙氨酸 HCL
- 中文别名:
- 4-乙炔基苯丙氨酸;化合物 T10142;4-乙炔基-L-苯丙氨酸;4-乙炔基-L-苯丙氨酸 HCL;(S)-2-氨基-3-(4-炔基苯基)丙酸
- CBNumber:
- CB02665148
- 分子式:
- C11H11NO2
- 分子量:
- 189.21
- MOL File:
- 278605-15-5.mol
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4-乙炔基-L-苯丙氨酸 HCL化学性质
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沸点:
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343.2±37.0 °C(Predicted)
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 2.22 mg/mL (11.73 mM)
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形态:
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Solid
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酸度系数(pKa):
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2.18±0.10(Predicted)
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颜色:
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Off-white to light yellow
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4-乙炔基-L-苯丙氨酸 HCL性质、用途与生产工艺
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
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Animal Model:
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Male Sprague-Dawley rats (200 g)
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Dosage:
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30 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
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4-乙炔基-L-苯丙氨酸 HCL
上下游产品信息
上游原料
下游产品
278605-15-5, 4-乙炔基-L-苯丙氨酸 HCL 相关搜索:
- 抑制剂
- 4-乙炔基苯丙氨酸
- (S)-2-氨基-3-(4-炔基苯基)丙酸
- 4-乙炔基-L-苯丙氨酸
- 化合物 T10142
- 4-乙炔基-L-苯丙氨酸 HCL
- 278605-15-5
- (S)-2-Amino-3-(4-ethynylphenyl)propanoic acid
- (2S)-2-amino-3-(4-ethynylphenyl)propanoic acid
- pEthynylphenylalanine,p Ethynylphenylalanine
- 4-Ethynylphenylalanine
- 4-Ethynyl-L-phenylalanine
- 4-Ethynyl-L-phenylalanine HCl
- L-Phenylalanine, 4-ethynyl-