4-乙炔基-L-苯丙氨酸 HCL
| 中文名称 | 4-乙炔基-L-苯丙氨酸 HCL |
|---|---|
| 中文同义词 | 4-乙炔基-L-苯丙氨酸 HCL;化合物 T10142;4-乙炔基-L-苯丙氨酸;(S)-2-氨基-3-(4-炔基苯基)丙酸;4-乙炔基苯丙氨酸 |
| 英文名称 | 4-Ethynyl-L-phenylalanine HCl |
| 英文同义词 | L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;4-Ethynyl-L-phenylalanine;4-Ethynylphenylalanine;pEthynylphenylalanine,p Ethynylphenylalanine;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid;(S)-2-Amino-3-(4-ethynylphenyl)propanoic acid |
| CAS号 | 278605-15-5 |
| 分子式 | C11H11NO2 |
| 分子量 | 189.21 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 278605-15-5.mol |
| 结构式 |  |
4-乙炔基-L-苯丙氨酸 HCL 性质
| 沸点 | 343.2±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：2.22 mg/mL（11.73 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.18±0.10(Predicted) |
| 颜色 | 米白色至浅黄色 |
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) 是一种高效、选择性的，可逆、竞争性的色氨酸羟化酶 (TPH) 抑制剂，其 Ki 值为 32.6 μM。
Ki: 32.6 μM (TPH)
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
| Animal Model: | Male Sprague-Dawley rats (200 g) |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |