4-乙炔基-L-苯丙氨酸 HCL
中文名称 | 4-乙炔基-L-苯丙氨酸 HCL |
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中文同义词 | 4-乙炔基-L-苯丙氨酸 HCL;化合物 T10142;4-乙炔基-L-苯丙氨酸 |
英文名称 | 4-Ethynyl-L-phenylalanine HCl |
英文同义词 | L-Phenylalanine, 4-ethynyl-;4-Ethynyl-L-phenylalanine HCl;4-Ethynyl-L-phenylalanine;4-Ethynylphenylalanine;pEthynylphenylalanine,p Ethynylphenylalanine;(2S)-2-amino-3-(4-ethynylphenyl)propanoic acid |
CAS号 | 278605-15-5 |
分子式 | C11H11NO2 |
分子量 | 189.21 |
EINECS号 | |
相关类别 | |
Mol文件 | 278605-15-5.mol |
结构式 | ![]() |
4-乙炔基-L-苯丙氨酸 HCL 性质
沸点 | 343.2±37.0 °C(Predicted) |
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密度 | 1.21±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:2.22 mg/mL(11.73 mM) |
形态 | 固体 |
酸度系数(pKa) | 2.18±0.10(Predicted) |
颜色 | 米白色至浅黄色 |
Ki: 32.6 μM (TPH)
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
).
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase.
Animal Model: | Male Sprague-Dawley rats (200 g) |
Dosage: | 30 mg/kg |
Administration: | Intraperitoneal injection |
Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |