贯叶金丝桃素
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- CAS号:
- 11079-53-1
- 英文名:
- HYPERFORIN
- 英文别名:
- HYPERFORIN;HYPERFORIN MIX(P);HYPERFORIN USP/EP/BP;Hyperforin (solution in Ethanol);Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-;methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-;4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE;(1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
- 中文名:
- 贯叶金丝桃素
- 中文别名:
- 海穿孔菌素;贯叶金丝桃素;贯叶金丝桃素MIX;高含量贯叶金丝桃素
- CBNumber:
- CB0273398
- 分子式:
- C35H52O4
- 分子量:
- 536.78
- MOL File:
- 11079-53-1.mol
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贯叶金丝桃素化学性质
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熔点:
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79-80℃
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比旋光度:
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D18 +41° (in ethanol)
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沸点:
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616.8±55.0 °C(Predicted)
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密度:
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1.010±0.06 g/cm3 (20 ºC 760 Torr)
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闪点:
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9℃
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储存条件:
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-20°C
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形态:
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solution
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酸度系数(pKa):
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4.8 (50% aq ethanol)
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CAS 数据库:
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11079-53-1
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贯叶金丝桃素性质、用途与生产工艺
贯叶金丝桃（HypericumperforatumL.）是藤黄科金丝桃属植物。1984年，Suzuki等首次发现贯叶金丝桃具有抗抑郁作用，并且疗效显著、副作用小。随着研究的深入，贯叶金丝桃的抗抑郁、抗病毒、抗肿瘤等作用越来越受到人们的关注。
贯叶金丝桃提取物的抗抑郁作用与贯叶金丝桃素的浓度密切相关，贯叶金丝桃素制剂的抗抑郁作用明显优于安慰剂，其疗效与标准抗抑郁药马普替林(maprotiline)、丙咪嗪(imipramine)、阿米替林(amitriptyline)相当，但不良反应少得多，治疗费用也相对较低。
叶金丝桃素低温超声提取工艺：称取10g粉碎好的贯叶金丝桃粉末，置500mL烧杯中，按体积比加入10倍量75%乙醇并混匀，加入适量的抗氧化剂，按照各种设定条件超声时间每次10min，提取3次，合并提取液，用氮吹仪挥去乙醇，利用冷冻干燥技术进行干燥，温度-60℃预冻4h，然后按照程序升温曲线的条件下干燥27h，即得贯叶金丝桃素提取物。贯叶金丝桃素对光和热不稳定，因此，在提取等整个工艺中，每一个环节应始终将温度控制在60℃以下且金丝桃素应避光保存于棕色瓶中。
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- C35H52O4
- 贯叶金丝桃素MIX
- 海穿孔菌素
- 高含量贯叶金丝桃素
- 贯叶金丝桃素
- 11079-53-1
- HYPERFORIN USP/EP/BP
- Bicyclo[3.3.1]non-3-ene-2,9-dione,4-hydroxy-6-methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
- Hyperforin (solution in Ethanol)
- HYPERFORIN MIX(P)
- (1R,5S)-4-Hydroxy-6-methyl-1,3,7β-tris(3-methyl-2-butenyl)-5-(2-methyl-1-oxopropyl)-6α-(4-methyl-3-pentenyl)bicyclo[3.3.1]non-3-ene-2,9-dione
- HYPERFORIN
- 4-HYDROXY-6R-METHYL-1R,3,7S-TRIS(3-METHYL-2-BUTENYL)-5S-(2-METHYL-1-OXOPROPYL)-6R-(4-METHYL-3-PENTENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE
- methyl-1,3,7-tris(3-methyl-2-buten-1-yl)-5-(2-methyl-1-oxopropyl)-6-(4-methyl-3-penten-1-yl)-,(1R,5S,6R,7S)-
- Bicyclo[3.3.1]non-3-ene-2,9-dione, 4-hydroxy-6-