PYRIDOSTATIN HYDROCHLORIDE
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- CAS号:
- 1781882-65-2
- 英文名:
- Pyridostatin hydrochloride
- 英文别名:
- Pyridostatin HCl;RR-82 hydrochloride;Pyridostatin hydrochloride
- 中文名:
- PYRIDOSTATIN HYDROCHLORIDE
- 中文别名:
- CBNumber:
- CB03035049
- 分子式:
- C31H33ClN8O5
- 分子量:
- 633.11
- MOL File:
- 1781882-65-2.mol
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PYRIDOSTATIN HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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形态:
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Solid
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颜色:
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White to off-white
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水溶解性:
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Water: 50 mg/mL (64.19 mM)
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PYRIDOSTATIN HYDROCHLORIDE性质、用途与生产工艺
Pyridostatin (RR82) hydrochloride 是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM)。Pyridostatin hydrochloride 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin hydrochloride 靶向原癌基因 Src。Pyridostatin hydrochloride 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。
Kd: 490 nM (G-quadruplexe)
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.
Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Cell Viability Assay
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Cell Line:
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Over 60 different cancer cell lines
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Concentration:
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10 μM
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Incubation Time:
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48 hours
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Result:
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Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines.
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PYRIDOSTATIN HYDROCHLORIDE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE
Pyridostatin hydrochloride | 1781882-65-2 | 5mg | 1120元 |
| 2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE
Pyridostatin hydrochloride | 1781882-65-2 | 10mM * 1mLin Water | 1268元 |
PYRIDOSTATIN HYDROCHLORIDE
生产厂家
1781882-65-2, PYRIDOSTATIN HYDROCHLORIDE 相关搜索:
- 1781882-65-2
- RR-82 hydrochloride
- Pyridostatin HCl
- Pyridostatin hydrochloride