PYRIDOSTATIN HYDROCHLORIDE
中文名称 | PYRIDOSTATIN HYDROCHLORIDE |
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中文同义词 | |
英文名称 | Pyridostatin hydrochloride |
英文同义词 | Pyridostatin hydrochloride;Pyridostatin HCl;RR-82 hydrochloride |
CAS号 | 1781882-65-2 |
分子式 | C31H33ClN8O5 |
分子量 | 633.11 |
EINECS号 | |
相关类别 | |
Mol文件 | 1781882-65-2.mol |
结构式 |
PYRIDOSTATIN HYDROCHLORIDE 性质
储存条件 | Store at -20°C |
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形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water: 50 mg/mL (64.19 mM) |
Kd: 490 nM (G-quadruplexe)
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.
Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Cell Viability Assay
Cell Line: | Over 60 different cancer cell lines |
Concentration: | 10 μM |
Incubation Time: | 48 hours |
Result: | Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 5mg | 1120元 |
2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mM * 1mLin Water | 1268元 |