298708-81-3
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- CAS号:
- 298708-81-3
- 英文名:
- Bay 41-4109
- 英文别名:
- Bay 41-4109;Bayer 41-4109;Bay 41 4109,Bay 414109;BAY-41-4109 (R-isomer);BAY41-4109; BAY-41-4109; BAYER 41-4109;methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-
- 中文名:
- 298708-81-3
- 中文别名:
- 化合物 T10480L
- CBNumber:
- CB03169580
- 分子式:
- C18H13ClF3N3O2
- 分子量:
- 395.76
- MOL File:
- 298708-81-3.mol
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298708-81-3化学性质
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沸点:
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475.3±45.0 °C(Predicted)
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密度:
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1.46±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 100 mg/mL (252.68 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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5.43±0.60(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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298708-81-3性质、用途与生产工艺
BAY 41-4109是人乙型肝炎病毒 (HBV) 的有效抑制剂，IC50值为 53 nM。
BAY 41-4109 is able to both accelerate and misdirect capsid assembly
in vitro
. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC
50
s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production
in vivo
by a mechanism that targets the viral capsid.
298708-81-3
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100029 | 298708-81-3
Bay 41-4109 | 298708-81-3 | 5mg | 1300元 |
| 2024/04/30 | HY-100029 | 298708-81-3
Bay 41-4109 | 298708-81-3 | 10mg | 2200元 |
298708-81-3, 298708-81-3 相关搜索:
- 化合物 T10480L
- 298708-81-3
- Bay 41 4109,Bay 414109
- BAY-41-4109 (R-isomer)
- 5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-
- Bayer 41-4109
- BAY41-4109; BAY-41-4109; BAYER 41-4109
- methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate
- Bay 41-4109