298708-81-3
| 中文名称 | 298708-81-3 |
|---|---|
| 中文同义词 | 化合物 T10480L |
| 英文名称 | Bay 41-4109 |
| 英文同义词 | Bay 41-4109;methyl (R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate;BAY41-4109; BAY-41-4109; BAYER 41-4109;Bayer 41-4109;5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-;BAY-41-4109 (R-isomer);Bay 41 4109,Bay 414109 |
| CAS号 | 298708-81-3 |
| 分子式 | C18H13ClF3N3O2 |
| 分子量 | 395.76 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 298708-81-3.mol |
| 结构式 |  |
298708-81-3 性质
| 沸点 | 475.3±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.46±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：100 mg/mL (252.68 mM)；水：< 0.1 mg/mL（不溶） |
| 酸度系数(pKa) | 5.43±0.60(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
IC50&Target: 53 nM (HBV)
BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro . Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC 50 s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100029 | 298708-81-3 Bay 41-4109 | 298708-81-3 | 5mg | 1300元 |
| 2024/04/30 | HY-100029 | 298708-81-3 Bay 41-4109 | 298708-81-3 | 10mg | 2200元 |