ASP 7663;ASP-7663;ASP7663
|
|
|
- CAS号:
- 1190217-35-6
- 英文名:
- ASP7663
- 英文别名:
- ASP7663;ASP7663 >=98% (HPLC);ASP 7663;ASP-7663;ASP7663;(E)-2-(7-Fluoro-1-isobutyl-2-oxoindolin-3-ylidene)acetic acid;(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid;Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-;pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663
- 中文名:
- ASP 7663;ASP-7663;ASP7663
- 中文别名:
- 化合物ASP7663;ASP 7663,TRPA1激活剂;(E)-2-(7-氟-1-异丁基-2-氧代吲哚啉-3-亚基)乙酸
- CBNumber:
- CB03959569
- 分子式:
- C14H14FNO3
- 分子量:
- 263.26
- MOL File:
- 1190217-35-6.mol
|
|
|
ASP 7663;ASP-7663;ASP7663化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
DMSO: 25 mg/ml,Ethanol: 25 mg/ml
-
|
-
形态:
-
A crystalline solid
-
|
-
颜色:
-
Light yellow to orange
-
|
ASP 7663;ASP-7663;ASP7663性质、用途与生产工艺
ASP7663 是具有口服活性的、选择性的 TRPA1 激动剂。ASP7663 具有抗便秘和抗腹痛的活性。
ASP7663 concentration dependently increases intracellular Ca
2+
concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC
50
values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice.
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
|
Animal Model:
|
CRD model (colorectal distension in rat).
|
|
Dosage:
|
1 and 3 mg/kg.
|
|
Administration:
|
Orally.
|
|
Result:
|
Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment.
|
ASP 7663;ASP-7663;ASP7663
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101907 | ASP7663 | | 1 mg | 419元 |
| 2024/11/08 | HY-101907 | ASP 7663;ASP-7663;ASP7663
ASP7663 | 1190217-35-6 | 5mg | 1000元 |
ASP 7663;ASP-7663;ASP7663
生产厂家
1190217-35-6, ASP 7663;ASP-7663;ASP7663 相关搜索:
- 抑制剂
- 合成有机化合物配体
- (E)-2-(7-氟-1-异丁基-2-氧代吲哚啉-3-亚基)乙酸
- ASP 7663,TRPA1激活剂
- 化合物ASP7663
- 1190217-35-6
- (E)-2-(7-Fluoro-1-isobutyl-2-oxoindolin-3-ylidene)acetic acid
- pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663
- ASP7663 >=98% (HPLC)
- Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-
- ASP 7663;ASP-7663;ASP7663
- (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
- ASP7663