ASP 7663;ASP-7663;ASP7663
| 中文名称 | ASP 7663;ASP-7663;ASP7663 |
|---|---|
| 中文同义词 | 化合物ASP7663;ASP 7663,TRPA1激活剂 |
| 英文名称 | ASP7663 |
| 英文同义词 | ASP7663;(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid;ASP 7663;ASP-7663;ASP7663;Acetic acid, 2-[7-fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]-, (2E)-;ASP7663 >=98% (HPLC);pain,ASP-7663,inhibit,TRP Channel,ASP7663,Transient receptor potential channels,Inhibitor,ASP 7663 |
| CAS号 | 1190217-35-6 |
| 分子式 | C14H14FNO3 |
| 分子量 | 263.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1190217-35-6.mol |
| 结构式 |  |
ASP 7663;ASP-7663;ASP7663 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO：25mg/mL，乙醇：25mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 浅黄至橙色 |
ASP7663 concentration dependently increases intracellular Ca
2+
concentration in human, rat, and mouse TRPA1 expressed in HEK293 cells in a similar manner, with respective EC
50
values (95% confidence interval [CI]) of 0.51 (0.40–0.66), 0.54 (0.41–0.72), and 0.50 (0.41–0.63) μmol/L.
ASP7663 concentration-dependently stimulates 5-HT release from QGP-1 cells, a lineage of TRPA1-expressing EC cells, with an EC50 value of 72.5 (52.6–99.9) μmol/L.
ASP7663 significantly improves the loperamide-induced delay in colonic transit in mice.
ASP7663 (orally, 0.3 and 1 mg/kg) significantly shortens the prolonged bead expulsion time caused by loperamide.
ASP7663 (orally, 1 and 3 mg/kg) exhibits inhibitory effects on colorectal distension in rat.
| Animal Model: | CRD model (colorectal distension in rat). |
| Dosage: | 1 and 3 mg/kg. |
| Administration: | Orally. |
| Result: | Significantly reduced the number of abdominal contractions evoked during CRD at pressures of 30, 45, and 60 mmHg. ASP7663 also reduced the number of abdominal contractions by intravenous treatment. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101907 | ASP7663 | 1 mg | 419元 | |
| 2024/04/30 | HY-101907 | ASP 7663;ASP-7663;ASP7663 ASP7663 | 1190217-35-6 | 5mg | 1000元 |