(RS)-(四唑-5-基)甘氨酸
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- CAS号:
- 138199-51-6
- 英文名:
- (RS)-(TETRAZOL-5-YL)GLYCINE
- 英文别名:
- C13738;LY 285265;Tet-glycine;Tetrazolyl Glycine;5-Tetrazolyl-glycine;(RS)-(Tetrazol-5-yl);(tetrazol-5-yl)glycine;L-(tetrazol-5-yl)glycine;(RS)-(TETRAZOL-5-YL)GLYCINE;aMino(2H-tetrazol-5-yl)acetic acid
- 中文名:
- (RS)-(四唑-5-基)甘氨酸
- 中文别名:
- (RS)-(四唑-5-基)甘氨酸;(RS)-(替硝唑-5-基)甘氨酸,强效NMDA激动剂;化合物(RS)-(TETRAZOL-5-YL)GLYCINE
- CBNumber:
- CB0429449
- 分子式:
- C3H5N5O2
- 分子量:
- 143.1
- MOL File:
- 138199-51-6.mol
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(RS)-(四唑-5-基)甘氨酸化学性质
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沸点:
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447.1±55.0 °C(Predicted)
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密度:
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1.804±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: 0.25mg/mL; PBS (pH 7.2): 0.2mg/mL
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形态:
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Powder
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酸度系数(pKa):
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1.04±0.10(Predicted)
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水溶解性:
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Soluble to 50 mM in water
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(RS)-(四唑-5-基)甘氨酸性质、用途与生产工艺
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) 是一种高效且选择性的 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂。(RS)-(Tetrazol-5-yl)glycine 对 GluN1/GluN2D 和 GluN1/GluN2A 的 EC50 分别为 99 nM，1.7 μM。(RS)-(Tetrazol-5-yl)glycine 诱导小鼠癫痫发作反应和 Fos。
EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [
3
H]CGS19755 (IC
50
=98 nM) and [
3
H]glutamate (IC
50
=36 nM) as ligands.
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [
3
H]kainate, or [
3
H]glycine (IC
50
s>30 μM).
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice.
(RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED
50
=0.071 mg/kg; i.p.) .
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Animal Model:
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C57BL/6 mice
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Dosage:
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1.25, 1.5 mg/kg
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Administration:
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IP
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Result:
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Induced seizure responses and Fos.
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(RS)-(四唑-5-基)甘氨酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/02/08 | HY-100839 | (RS)-(四唑-5-基)甘氨酸
(RS)-(Tetrazol-5-yl)glycine | 138199-51-6 | 1 mg | 300元 |
| 2025/02/08 | HY-100839 | (RS)-(四唑-5-基)甘氨酸
(RS)-(Tetrazol-5-yl)glycine | 138199-51-6 | 5 mg | 760元 |
138199-51-6, (RS)-(四唑-5-基)甘氨酸 相关搜索:
- 抑制剂
- 化合物(RS)-(TETRAZOL-5-YL)GLYCINE
- (RS)-(替硝唑-5-基)甘氨酸,强效NMDA激动剂
- (RS)-(四唑-5-基)甘氨酸
- 138199-51-6
- 2H-Tetrazole-5-acetic acid, α-amino-
- Fos,iGluR,GluN2D,LY-285265,Ionotropic glutamate receptors,inhibit,Inhibitor,(RS)(Tetrazol5yl)glycine,GluN1,(RS) (Tetrazol 5 yl)glycine,GluN2A,LY285265,NMDA,seizure
- L-(tetrazol-5-yl)glycine
- (RS)-(Tetrazol-5-yl)glycine/LY285265
- Tetrazolyl Glycine
- 2-Amino-2-(2H-tetrazol-5-yl)acetic acid
- (RS)-(Tetrazol-5-yl)
- 2H-Tetrazole-5-acetic acid, α-amino-
- LY 285265
- alpha-Amino-2H-tetrazole-5-acetic acid
- 2H-Tetrazole-5-acetic acid, a-amino-
- Amino-(1H-tetrazol-5-yl)-acetic acid
- aMino(2H-tetrazol-5-yl)acetic acid
- Tet-glycine
- C13738
- 5-Tetrazolyl-glycine
- (tetrazol-5-yl)glycine
- (RS)-(TETRAZOL-5-YL)GLYCINE