(RS)-(四唑-5-基)甘氨酸
| 中文名称 | (RS)-(四唑-5-基)甘氨酸 |
|---|---|
| 中文同义词 | (RS)-(四唑-5-基)甘氨酸;(RS)-(替硝唑-5-基)甘氨酸,强效NMDA激动剂;化合物(RS)-(TETRAZOL-5-YL)GLYCINE |
| 英文名称 | (RS)-(TETRAZOL-5-YL)GLYCINE |
| 英文同义词 | (RS)-(TETRAZOL-5-YL)GLYCINE;(tetrazol-5-yl)glycine;5-Tetrazolyl-glycine;C13738;Tet-glycine;aMino(2H-tetrazol-5-yl)acetic acid;Amino-(1H-tetrazol-5-yl)-acetic acid;2H-Tetrazole-5-acetic acid, a-amino- |
| CAS号 | 138199-51-6 |
| 分子式 | C3H5N5O2 |
| 分子量 | 143.1 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 138199-51-6.mol |
| 结构式 |  |
(RS)-(四唑-5-基)甘氨酸 性质
| 沸点 | 447.1±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.804±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 二甲基亚砜：0.25mg/mL； PBS（pH 7.2）：0.2mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.04±0.10(Predicted) |
| 水溶解性 | Soluble to 50 mM in water |
EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [
3
H]CGS19755 (IC
50
=98 nM) and [
3
H]glutamate (IC
50
=36 nM) as ligands.
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [
3
H]kainate, or [
3
H]glycine (IC
50
s>30 μM).
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice.
(RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED
50
=0.071 mg/kg; i.p.) .
| Animal Model: | C57BL/6 mice |
| Dosage: | 1.25, 1.5 mg/kg |
| Administration: | IP |
| Result: | Induced seizure responses and Fos. |