射干苷 化学药品说明书川射干—射干苷的测定—高效液相色谱法|药物分析方法信息
射干苷提取自鸢尾科植物射干的根茎,可用于含量测定、鉴定、药理实验等。也是一种乳酸脱氢酶(LDH)抑制剂。
Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein. Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation. Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP.