LANREOTIDE ACETATE
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- CAS号:
- 2378114-72-6
- 英文名:
- Lanreotide acetate
- 英文别名:
- BIM 23014 (acetate);Lanreotide acetate (108736-35-2 free base);Lanreotide,Lanreotide acetate,inhibit,hormone,apoptosis,pituitary,BIM23014,Inhibitor,BIM-23014,GH3 cells,tumor,adenoma,GH-secreting,BIM 23014
- 中文名:
- LANREOTIDE ACETATE
- 中文别名:
- 化合物LANREOTIDE ACETATE
- CBNumber:
- CB05984073
- 分子式:
- C56H73N11O12S2
- 分子量:
- 1156.39
- MOL File:
- 2378114-72-6.mol
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LANREOTIDE ACETATE化学性质
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形态:
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Solid
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颜色:
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White to off-white
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LANREOTIDE ACETATE性质、用途与生产工艺
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一种天然生长抑素肽的类似物，是生长激素 growth hormone (GH)的生理抑制剂。Lanreotide 也具有抗肿瘤作用。
Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.
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Animal Model:
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Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)
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Dosage:
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2.5, 5, 10 mg/kg
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Administration:
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Subcutaneous; daily for 5 days
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Result:
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Produced tumor growth inhibition.
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LANREOTIDE ACETATE
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/16 | P1088 | LANREOTIDE ACETATE
Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
| 2024/01/16 | P1088 | LANREOTIDE ACETATE
Lanreotide acetate | 2378114-72-6 | 25mg | 2678.21元 |
2378114-72-6, LANREOTIDE ACETATE 相关搜索:
- 药靶配体
- 多肽
- 化合物LANREOTIDE ACETATE
- 2378114-72-6
- Lanreotide,Lanreotide acetate,inhibit,hormone,apoptosis,pituitary,BIM23014,Inhibitor,BIM-23014,GH3 cells,tumor,adenoma,GH-secreting,BIM 23014
- Lanreotide acetate (108736-35-2 free base)
- BIM 23014 (acetate)