LANREOTIDE ACETATE
| 中文名称 | LANREOTIDE ACETATE |
|---|---|
| 中文同义词 | 化合物LANREOTIDE ACETATE |
| 英文名称 | Lanreotide acetate |
| 英文同义词 | BIM 23014 (acetate);Lanreotide acetate (108736-35-2 free base);Lanreotide,Lanreotide acetate,inhibit,hormone,apoptosis,pituitary,BIM23014,Inhibitor,BIM-23014,GH3 cells,tumor,adenoma,GH-secreting,BIM 23014 |
| CAS号 | 2378114-72-6 |
| 分子式 | C56H73N11O12S2 |
| 分子量 | 1156.39 |
| EINECS号 | |
| 相关类别 | 多肽 |
| Mol文件 | 2378114-72-6.mol |
| 结构式 |  |
LANREOTIDE ACETATE 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一种天然生长抑素肽的类似物，是生长激素 growth hormone (GH)的生理抑制剂。Lanreotide 也具有抗肿瘤作用。
Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.
| Animal Model: | Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice) |
| Dosage: | 2.5, 5, 10 mg/kg |
| Administration: | Subcutaneous; daily for 5 days |
| Result: | Produced tumor growth inhibition. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
| 2024/01/16 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 25mg | 2678.21元 |